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XB-JOB-1005
Research Associate
Lab None Closing Date 2017-12-02
Employer Name UCL Cancer Institute Posting Date 2017-11-08
Employer URL http://www.ucl.ac.uk/cancer/research/department-cancer-biology/cell-cycle-control-group Salary 30,316 to 31,967 pounds per annum
Contact None    
Location United Kingdom,  ,  London    
Submit Email    

Job URL http://www.ucl.ac.uk/hr/jobs/

Job Description

The Cell Cycle Control Group headed by Professor Hiro Yamano is seeking for a Research Associate. 

The group has a broad interest in cell division cycle, growth and differentiation control by ubiquitin-mediated proteolysis, with particular interests in the regulation of the anaphase-promoting complex/cyclosome (APC/C), one of the most important ubiquitin ligase in our body.

Further details of our research interests can be found at http://www.ucl.ac.uk/cancer/research/department-cancer-biology/cell-cycle-control-group 

The aim of this post is to use the newly developed , functional biochemistry (Fujimitsu, K. et al., Science 352, 2016) ,together with a combination of cellular, genetic, structural and mass spectrometry tools and discover novel mechanisms of the activation and inactivation of the APC/C-ubiquitin system. 

The post-holder will study either:
1) phosphatase-driven APC/C regulation, 
2) the role and underlying mechanisms of different APC/C co-activators (Cdc20, Cdh1) working in the control of cell cycle or 
3) mechanisms and impacts of post-translational modifications of the APC/C-ubiquitin system in health and disease. 

The post is funded for 2 years in the first instance.

The successful candidate will have a PhD (or be studying for) a PhD in biological sciences with focus on cell cycle, proteolysis, cell signaling and related disciplines.
Experience of performing a range of molecular biology techniques, biochemistry and purification techniques are essential. 
The post-holder should also have substantial experience in protein phosphatase or kinase assay or mass spectrometry analysis. 
Experience in Xenopus egg extracts or culture system, cell cycle field and ubiquitin field is highly desirable. 

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary 30,316 to 31,967 pounds per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).

For further details about the vacancy and how to apply online please go to http://www.ucl.ac.uk/hr/jobs/ and search on Reference Number 1668632


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