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PhD position: Developmental epigenetics in Xenopus embryos .
Lab Niehrs Lab Closing Date 2017-11-15
Employer Name Niehrs Lab, The Institute of Molecular Biology Posting Date 2017-10-02
Employer URL Salary
Contact None    
Location Germany,  ,  Mainz    
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Job Description

In this project we will carry out a screen for novel epigenetic and demethylation regulators in Xenopus (frog) embryos, where microinjection yields facile access to functional analysis of gene function. We will misexpress candidate epigenetic regulators by mRNA overexpression and antisense Morpholino injection to score for interesting developmental phenotypes. Candidate genes will then be studied by next generation sequencing, including genome-wide gene expression (RNA-seq) to monitor marker gene expression changes and DNA methylation (bisulfite-seq) analysis.  Further characterization of changes in embryonic gene expression will be followed up by genome wide ChIP-seq and bioinformatics analysis.  We will employ a systems biology approach for the understanding of the candidates gene function. 

We offer
-The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
- A stimulating, diverse and international research environment
-Advanced training opportunities
- A fully funded PhD position

Required qualifications
- Master or Diploma
- Motivation to solve complex biological problems
- Excellent communication skills

Further requirement
- 2 Letters of reference

Duration of stipend/salary: 3 years, with the possibility of extension
Starting date: 1 March 2018 or later
Deadline for registration (exclusively online via web form): 15 November 2017

For further questions and contact information please check our website:

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