Research InterestsEarly patterning by TGFß and ubiquitin pathways
Research AreaWe are interested in the molecular mechanisms of early embryonic cell fate determination and pattern formation by inductive signaling. Primary focus is on signal transduction by TGFß pathways, either canonical Smad or non-canonical (e.g. p38 MAPK) pathways. Present investigations seek to identify and define the biochemical and embryonic functions of modulators and transcriptional cofactors of Smad signal transducers. Recent examples include Smurf ubiquitin ligases, and the Dril1 transcription factor. Other new modulators of BMP and nodal/Vg1/activin signaling are in the analysis pipeline. We are also interested in the general question of how regulation of protein stability affects early development. To this end we are investigating the embryonic functions and biochemical targets of E3 ubiquitin ligases.
Current MembersThomsen, Gerald H. (Principal Investigator/Director)
Iwasaki, Yasuno (Post-doc)
Lee, Youngja (Undergraduate Student)
ContactInstitution: Stony Brook University Address:
Web Page: http://www.thomsenlab.org