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XB-LAB-141

Green Lab

Embryonic patterning and cell polarity

King's College London

King's College London
Department of Craniofacial Development
Guy's Tower, Floor 27
London
SE1 9RT, United Kingdom

Personal Phone: +44 207 188 1794
General/Lab Fax: +44 207 188 1795

People

Green, Jeremy B. (Principal Investigator/Director)

Research Area

My lab uses Xenopus frog embryos and sometimes zebrafish and cultured mammalian cells to investigate basic mechanisms in development. This includes the molecular mechanisms governing - Embryo and cell polarity, - Morphogen growth factor action (activin, Wnts) - Tissue morphogenesis - Signal transduction (GSK3, Wnts) - Differentiation of mesoderm and - Specification of neurons (neurogenesis) and ciliated cells Molecules of interest include the canonical and non-canonical Wnt pathways, the PAR polarity proteins, especially the kinases PAR1 and PAR4, atypical PKC and glycogen synthase kinase (GSK3). My group works within a lively Developmental Biology Department at the Guy's Hospital campus of King's College London with fabulous views over the heart of central London. We are beginning to apply our morphogen expertise to directed differentiation of embryonic stem cells.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556