Dynamique de la chromatine
Based in the Pavillon Pasteur on the central Paris site, the Nuclear Dynamics and Genome Plasticity unit, with shared supervision of CNRS and in partnership with UPMC, consists of 1 technological platform and 4 teams studying epigeneticsEpigenetics concerns heritable changes in genome function that cannot be explained by changes in DNA sequence. Epigenetic differences in gene expression underlie the diversity of cell types that form during the development of multicellular organisms: all cells have the same genetic information but the manner in which it is read differs in the various cell types. Once established, many epigenetic changes are stably maintained throughout cell division and the lifetime of the organism, but they can be reversed in the germ line. Epigenetic marks can also arise or be lost spontaneously leading to incorrect gene expression (epimutations), for example, in diseases such as cancer. in development and disease. A major theme in the unit is the fundamental question of the maintenance of both genetic and epigenetic information (see websites :www.epigenome-noe.net and www.epigenesys.org). The integrity of both information can be compromised under genotoxic stresses as well as during the normal cellular metabolism. To evaluate genotoxic risks (environmental or under medical conditions) interactions with the Medical Section will be pursued.
Our approach is based on an integrated perception of genome organisation ranging from the nucleus in the cell up to an entire organism, incorporating developmental and cell cycle changes. Specific areas are concerned: 1) the importance of factors involved in chromatin dynamics (G Almouzni's group) ; 2) the epigenetic plasticity in the control of the polarity in the embryo (N Dostatni's group) ; 3) compartimentalization and dynamics of nuclear functions (A Taddei's group) ; 4) chromosome dynamics and recombination (V Borde's group), and 5) chromatin pathways to genome integrity (M Papamichos-Chronakis group) .