Nongenomic steroid responses
University of Rochester Medical Center
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave
Rochester, New York
General/Lab Fax: (585) 273-1288
Hammes, Stephen R.
The Hammes laboratory studies how steroidogenesis and steroid signaling in the ovary regulate ovarian development and function. First, they use frog and mouse models of steroid-triggered oocyte maturation (meiotic resumption) to study transcription-independent, or nongenomic, steroid signaling. The laboratory has made many important discoveries regarding the roles of androgens, androgen receptors, and G proteins in regulating the maturation process. They are interested in studying how this nongenomic androgen signaling might affect ovarian development and function in diseases of androgen excess, such as polycystic ovarian syndrome (PCOS).