Hoppler Research Group
Research InterestsWnt signalling in Xenopus Develooment
Research AreaThe tissues and organs of developing embryos are organised by cell-to-cell signalling. These interactions are mediated by a relatively small number of signalling molecules. These signals are repeatedly used at different stages of development and in different tissues of the embryo. Wnts are one important class of such signalling molecules. They are secreted glycoproteins which function as cell-to-cell signals in develomental processes in all multicellular animals examined. Abnormally activated Wnt signalling is also involved in certain types of tumours such as breast and colon cancer.
Current MembersHoppler, Stefan P. (Principal Investigator/Director) Contact
Additional InformationWe want to understand the normal role of Wnt signalling in patterning the developing vertebrate embryo. Where and when are Wnts used during embryogenesis and what is their function in different organs and at different stages? We have recently analysed the molecular mechanisms of tissue-specific Wnt signalling and are currently studying Wnt function in heart and brain development. We use Xenopus as our model system and apply modern techniques, such as transgenesis and antisense oligos.
ContactInstitution: University of Aberdeen Address:
Institute of Medical Sciences
University of Aberdeen
Cell and Developmental Biology Program
AB25 2ZD, United Kingdom
Web Page: http://www.abdn.ac.uk/~bms243Personal Phone: +44 (0)1224 437383
Personal Fax: +44 (0)1224 437384
General/Lab Phone: +44 (0)1224 437519