Cell-Cell Adhesion and Migration
National Cancer Institute
National Cancer Institute-Frederick
Building 560, room 22-90D
General/Lab Fax: 301-846-5632
Our current research interests are aimed toward examining the mechanism by which Eph receptor tyrosine kinases and their ephrin ligands signal events affecting cell-cell adhesion and morphogenetic movements. From the elucidation of these signal transduction pathways we may improve our understanding of oncogenesis. The cell-cell adhesion system plays a major role in normal development and morphogenesis. Inactivation of this adhesion system is thought to play a critical role in cancer invasion and metastasis. Our laboratory is currently investigating the role of the Xenopus Eph receptor tyrosine kinases and ephrinB transmembrane ligands in cell signaling and function using the Xenopus oocyte and embryo systems. At present, our emphasis is placed upon the mechanism by which these Eph family members send signals affecting morphogenetic movements and exhibit crosstalk with the fibroblast growth factor (FGF) signaling pathway.