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XB-LAB-44

Moon Lab

Research Interests

Wnt signalling

Research Area

Wnts are members of a conserved family of secreted proteins that activate multiple receptor-mediated signal transduction pathways during embryonic development and in adults. The best-understood pathway, the Wnt/β-catenin network, stabilizes β-catenin, resulting in its accumulation in the nucleus, where it regulates transcription. There are also one or more noncanonical Wnt networks that signal through different mechanisms. Our lab is focused on identifying the roles of Wnt signaling networks, dissecting the molecular and cellular mechanisms by which this signaling occurs, and applying this knowledge to illuminate how Wnt signaling participates in disease processes and in responses to acute injury.

Current Members

Moon, Randall T. (Principal Investigator/Director)

Alumni


Contact

Institution: University of Washington

ILAR Code: Rtmn

Address:
University of Washington
HHMI/Pharmacology
Box358056
Seattle, WA
98195, USA

Web Page: http://faculty.washington.edu/rtmoon/

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