Research InterestsWnt signalling
Research AreaWnts are members of a conserved family of secreted proteins that activate multiple receptor-mediated signal transduction pathways during embryonic development and in adults. The best-understood pathway, the Wnt/β-catenin network, stabilizes β-catenin, resulting in its accumulation in the nucleus, where it regulates transcription. There are also one or more noncanonical Wnt networks that signal through different mechanisms. Our lab is focused on identifying the roles of Wnt signaling networks, dissecting the molecular and cellular mechanisms by which this signaling occurs, and applying this knowledge to illuminate how Wnt signaling participates in disease processes and in responses to acute injury.
Current MembersMoon, Randall T. (Principal Investigator/Director)
ContactInstitution: University of Washington ILAR Code: Rtmn Address:
University of Washington
Web Page: http://faculty.washington.edu/rtmoon/