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XB-LAB-467

Reversade Laboratory

Xenopus Modelling of Human diseases

Institute of Medical Biology

Laboratory of Human Embryology
Institute of Medical Biology
A*STAR
8A Biomedical Grove
05-39 Immunos
Singapore
138648, Singapore

www.reversade.com

Personal Phone: (+65) 6464 2006
General/Lab Fax: (+65) 6407 0169

People

Reversade, Bruno (Principal Investigator/Director)
Xue, Shifeng (Post-doc)

Research Area

Our laboratory studies the development of the human embryo, and genetic orphan diseases. To understand how embryogenesis proceeds, we investigate inherited disorders that cause birth defects. To gain understanding of biological processes as diverse as cancer, cognition, development, sleep or ageing, we investigate familial cases that show extreme example for these traits. Concretely to uncover genes preventing ageing, we will study patients that age prematurely or people that do not appear to age. Once we have uncovered the genetic variant responsible for a given disease or trait, we make use of patient's cells and animal models to examine the trait's aetiology or disease pathogenesis. We use of Human, Mice, Frog, Zebrafish and Drosophila to examine human pathologies.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556