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XB-LAB-50

Roberts Lab

Function of CNS

University of Bristol

University of Bristol
School of Biological Sciences
Bristol
United Kingdom

www.bio.bris.ac.uk/research/neuro/xgroup.htm

People

Roberts, Alan (Principal Investigator/Director) Contact

Research Area

We use embryos and young tadpoles of the frog Xenopus to ask how nervous systems work at the cellular level, develop to form the correct connections, and are organised to allow animals to behave. Our methods include: analysis of behaviour, whole-cell patch recording, neuron imaging, network modelling. See examples of our projects. The young Xenopus tadpole provides a very simple model animal with limited behaviour. It can swim either spontaneously or when touched anywhere on the body. A pineal eye detects dimming which speeds up swimming. The tadpole stops swimming when the head bumps into solid objects and the tadpole sticks to things with mucus secreted by a cement gland on the head. If the tadpole is held it can make stronger struggling movements.tadpole swimming This simple behaviour is coordinated by an extremely basic nervous circuit with very few differentiated classes of neuron. For example, at the time of hatching, the spinal cord appears to have only 8 different classes of neuron but the spinal tadpole can still swim. Simple methods for testing the behavioural responses of normal and genetically manipulated tadpoles are given.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556