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XB-LAB-57

Sargent Lab

Neural crest and epidermal development

NICHD,NIH

NICHD,NIH
Building 6B, Room 412
6 Center Drive
Bethesda, MD
20892, USA

sargentlab.nichd.nih.gov

People

Sargent, Tom D. (Principal Investigator/Director)

Research Area

The Section on Vertebrate Development laboratory is headed by Dr. Tom Sargent. The focus of our group is on ectodermal development, especially on epidermis and neural crest and the relationship between these two derivatives. Our primary animal model system is the frog Xenopus laevis, but we also work with zebrafish. Microarray analysis of Xenopus ectodermal cells in which the transcription factor AP2alpha has been manipulated resulted in the identification of many regulatory targets for this factor, including genes expressed in epidermis and in the neural crest. The long term goal of the lab is to understand the regulation of such genes and how they function in early embryonic development and in disease.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556