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XB-LAB-615

The Haccard-Jessus Laboratory

Biology of the Oocyte

Laboratoire de Biologie du Développement

Paris
France

bio-dev.snv.jussieu.fr/umr7622/labo/fichelabos.php?idlabo=14&lang=an

People

Jessus, Catherine (Principal Investigator/Director)
Dupré, Aude I. (Research Associate/Assistant)

Research Area

Our team is interested on studying three steps of meiotic maturation using Xenopus oocyte: - What regulate the activation of MPF in response to steroid hormones? Our researches are mainly focused on the respective contribution of kinases (Cdk1 and MAPK) and phosphatases (PP1 and PP2A) - What is the molecular mechanism inhibiting DNA replication during the meiosis I-meiosis II transition; this inhibition being essential for the formation of a haploid gamete? - Which mechanisms arrest the oocyte in metaphase II? Understanding the cell cycle regulation in meiosis is not only critical for reproduction and early development, it also helps us to decipher the process of tumoregenesis as cancer often results from the misregulation of cell division.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556