The Haccard-Jessus Laboratory
Biology of the Oocyte
Laboratoire de Biologie du Développement
Our team is interested on studying three steps of meiotic maturation using Xenopus oocyte: - What regulate the activation of MPF in response to steroid hormones? Our researches are mainly focused on the respective contribution of kinases (Cdk1 and MAPK) and phosphatases (PP1 and PP2A) - What is the molecular mechanism inhibiting DNA replication during the meiosis I-meiosis II transition; this inhibition being essential for the formation of a haploid gamete? - Which mechanisms arrest the oocyte in metaphase II? Understanding the cell cycle regulation in meiosis is not only critical for reproduction and early development, it also helps us to decipher the process of tumoregenesis as cancer often results from the misregulation of cell division.