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XB-LAB-628

Davidson Laboratory

Morphogenesis and Developmental Biomechanics

University of Pittsburgh

Dept. Bioengineering
Swanson School of Engineering
University of Pittsburgh
Pittsburgh, PA
15213, USA

www.engr2.pitt.edu/ldavidson/

People

Davidson, Lance A. (Principal Investigator/Director)

Research Area

Cells and tissues are shaped by mechanical forces early during development to produce the basic body plan and establish functional organs. Our group combines experimental and theoretical approaches to reverse-engineer these mechanical inherently mechanical processes. Our experimental methods include classical embryological, modern cell biological ones combined with new synthetic systems biology methods.

Additional Information

Projects: Cytoskeletal control and physical mechanics of convergent extension and axis elongation. Cell and tissue mechanics of mesenchymal sheet migration, spreading, and engulfment. Molecular and mechanical mechanisms that control cell contraction. The regulation of cell polarity and tissue movements that shape the heart forming region.

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556