Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.


XB-LAB-772

Lienkamp Lab

Research Interests

Kidney development and disease

Research Area

Our group is interested in embryonic renal development and disease. Which molecular and structural events lead to the formation of a functioning kidney? How these events are disrupted in hereditary renal diseases is a major focus of our work. How do renal tubules form? The kidney is a highly complex, but well-structured organ. We are especially interested in how renal tubules assume and maintain their shape. Using the embryonic kidney of Xenopus, we found that extensive cell migration and rearrangement occurs during tubule formation. Direction to these movements is provided by distinct molecular signals during renal morphogenesis.

Current Members

Lienkamp, Soeren S. (Principal Investigator/Director) Contact

Alumni


Additional Information

What are the molecular causes of hereditary renal disease? A number of genetic renal diseases can occur early in life and have severe consequences for the affected patients. We try to understand how defective molecules lead to disrupted structural renal development, for example in congenital anomalies of the kidney and urinary tract (CAKUT). Together with a large international team, we identified a novel ciliopathy gene that causes the rare cystic kidney disease nephronophthisis, when mutated.

Contact

Institution: University Hospital Freiburg

Address:
Freiburg, Baden-W├╝rttemberg 79106
Germany

Web Page: www.nephrolab.org/groups/soeren-lienkamp/

Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.1
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556