Research InterestsCellular and regenerative biology
Research AreaResearch Summary: The business of Ca2+ signaling is one of information delivery, and it’s hard to think of any cell process that is not regulated by Ca2+. Ca2+ signals also direct cell fate, and we are interested in the role of Ca2+ in directing stem cell differentiation and neurogenesis. Our current work examines regeneration of planarian flatworms as a simple paradigm for understand how Ca2+ signals bias regeneration toward CNS formation. We are examining whether ‘pharmacological engineering’ – using drugs to engage particular Ca2+ fluxes in vivo – can be used to promote neurogenesis. This is pure, simple, enjoyable basic science: with potential impact for studying human diseases from neurodegenerative conditions to a surprising relevance to infectious diseases that infect millions of people worldwide.Our breadth in pursuing problems with diverse approaches – from single molecule-level investigations into cell signaling architecture up to tissue regeneration studies in vivo – represents our mojo that trainees must have broad scope in bringing the best suited methods to bear on key research questions that motivate them.
Current MembersMarchant, Jonathan S. (Principal Investigator/Director) Contact
ContactInstitution: Medical College of Wisconsin Address:
Cell Biology, Neurobiology & Anatomy