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Profile Publications(16)
XB-PERS-1190

Karel Dorey

Independant Research Fellow

University of Manchester
Faculty of Life Sciences
The Healing Foundation Centre
Michael Smith Building
Oxford Road
Manchester
M13 9PT, United Kingdom

karel.dorey@manchester.ac.uk
http://personalpages.manchester.ac.uk/staff/karel.dorey/Dorey_Lab/Home.html

Phone:  0044 (0)1612751684

Research Description

In my laboratory, we aim to understand how Receptors Tyrosine Kinases (RTKs) can elicit a precise cellular response in the complex environment of the organism. To this end, we are investigating the molecular mechanisms controlling the activity of intracellular signalling pathways downstream of RTKs during Xenopus development. We are particularly interested in the role of RTK signalling during gastrulation and during neural development and maturation. These are two very different systems, allowing us to ask complementary questions about the mechanisms of action of RTKs during embryonic development.

During gastrulation, Fibroblast Growth Factor (FGF) plays an essential role for two very important developmental events: mesoderm specification and morphogenetic movements. Gastrulation is therefore a relatively simple model to study how the same signal (FGF) is interpreted differently by mesodermic cells.

During motor neurons (MNs) development, we have recently reported that another RTK (TrkB and its ligand BDNF) has a crucial role in regulating axonal branching (Panagiotaki et al. 2011). Whilst axonal branching plays an essential role in allowing the formation, refinement, and maintenance of functional neural circuits, the mechanisms regulating branching are poorly understood. Our work places us in a unique position to elicidate how RTK signalling controls cell shape (or "unicellular morphogenesis"). In the longer term, we aim to use this knowledge to improve spinal cord repair and regeneration following injury.

Lab Memberships

Dorey lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556