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Profile Publications(2)
XB-PERS-1624

Lauren K. Waldron

Graduate Student

104 Schultz Street
Chapel Hill, NC
27514, USA

Research Description

A series of clinical studies has provided direct evidence of a role for members of the T-box transcription factor family in heart development and human disease.  Specifically, mutations in Tbx5 have been associated with Holt-Oram Syndome (HOS), an autosomal dominant disorder characterized by a wide array of cardiac abnormalities, including ventral septal defects (VSD), atrial septal defects (ASD), and conduction abnormalities.  Despite the crucial role for TBX5 in development and disease, little is known about the mechanisms by which TBX5 functions.  We are using Xenopus transgenesis and bioassays in order to determine the mechanisms by which post-translational modifications can potentially affect TBX5 transcriptional activation.

Lab Memberships

Conlon Lab (Graduate Student)

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