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Profile Publications(62)
XB-PERS-1997

Rebecca Heald

Professor


bheald@calmail.berkeley.edu
http://mcb.berkeley.edu/labs/heald/index.html

Research Description

Investigating mechanisms of mitosis and size control in Xenopus.

Our interdisciplinary approaches take advantage of cytoplasmic extracts prepared from eggs of the frog Xenopus laevis that reconstitute mitotic chromosome condensation and spindle assembly and function in vitro. To study mechanisms of spindle and organelle size control, we utilize a smaller, related frog, Xenopus tropicalis, to investigate inter-species scaling, and extracts prepared from fertilized eggs at different stages of embryogenesis to study developmental scaling. We seek to provide new insight into the underlying principles of spindle assembly and biological size control, as well as the molecular basis of variation that contributes to genomic instability and evolution.

Lab Memberships

Heald Lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556