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Profile Publications(16)
XB-PERS-2954

Thomas U. Mayer

Department of Biology and
Konstanz Research School Chemical Biology
University of Konstanz
Universitätsstr. 10
p.o. box M 613
Konstanz
78457, Germany

thomas.u.mayer@uni-konstanz.de
http://www.uni-konstanz.de/thomasmayer/

Research Description

Our research focuses on mitosis and meiosis in higher eukaryotes. 

Particularly, we are interested in: 

i) how kinesins contribute to chromosome congression in mammalian cells
ii) how anaphase onset is controlled by the ubiquitin/proteasome system
iii) how cytokinesis is synchronized with chromosome segregation.

For these studies we combine molecular and cell biological approaches with biochemistry and live-cell microscopy studies.
In addition to siRNAs, we apply cell-permeable small molecule inhibitors to modulate the activity of proteins in living cells, an approach termed “chemical biology”.

Lab Memberships

Mayer Lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556