Thomas U. Mayer
Our research focuses on mitosis and meiosis in higher eukaryotes. Particularly, we are interested in: i) how kinesins contribute to chromosome congression in mammalian cells ii) how anaphase onset is controlled by the ubiquitin/proteasome system iii) how cytokinesis is synchronized with chromosome segregation. For these studies we combine molecular and cell biological approaches with biochemistry and live-cell microscopy studies. In addition to siRNAs, we apply cell-permeable small molecule inhibitors to modulate the activity of proteins in living cells, an approach termed “chemical biology”.
Lab MembershipsMayer Lab (Principal Investigator/Director)
Department of Biology and
Konstanz Research School Chemical Biology
University of Konstanz
p.o. box M 613