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Profile Publications(19)
XB-PERS-3847

Dr.  Hironori Funabiki

Professor

The Rockefeller University
1230 York Avenue
New York, NY
10065, USA

funabih@rockefeller.edu
http://lab.rockefeller.edu/funabiki/

Phone:  2123277291

Research Description

Our lab use Xenopus egg extracts to study structure and function of chromosomes. Highlights of our accomplishments are: to demonstrate that the chromosomal passenger complex (CPC) is required for chromatin-induced spindle assembly; to demonstrate importance of CPC association with chromatin and microtubules to activate Aurora B and spindle assembly; to establish the method to identify proteins that selectively interact with double stranded DNA ends, nucleosomes or specific histone modifications in Xenopus egg extracts; to demonstrate the importance of microtubule dynamics in functional nuclear envelope formation; to establish a method to reconstitute nucleosome functions using recombinant histones and synthetic DNA in histone H3-H4 depleted extracts.

Lab Memberships

Funabiki Lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556