Dr. Zhihua Jiang
PositionProfessor of of Comparative Genomics
COMPARATIVE RNA BIOLOGY Transcriptome analysis is fundamental to understanding the biochemical, cellular, physiological and environmental systems involved in the complex phenotypes that affect development, growth, reproduction and well-being in human and animals. In mammals, up to 75% of genes use alternative promoters, isoforms or polyadenylation sites, contributing greatly to transcriptome flexibility, diversity and dynamics. The long-term goal of our Comparative RNA Biology program is to create state-of-the-art tools for profiling the full transcriptome that will advance the field of functional genomics and increase its applicability to solve unmet problems in human health and animal productivity. We believe that accurate profiling of transcript variants will promote the discovery of genetic mutations that underlie complex phenotypes, aid in the selection of regulatory switch units for functional characterization, and discover alternative variants that can be used for disease diagnosis and drug discovery in humans and for biomarker selection in animals. Specific Research Areas: Development of next-generation sequencing tools for profiling of alternative transcripts. Development of alternative transcript resources in animals and model organisms. Development of animal models to understand alternative transcripts and multi-functions of genes.
Lab MembershipsJiang Lab (Principal Investigator/Director)
Washington State University