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Profile Publications(25)
XB-PERS-574

Caroline Hill

Research Scientist & Group Leader

London Research Institute
Lincoln’s Inn Fields Laboratories
44 Lincoln’s Inn Fields
London
WC2A 3LY, United Kingdom

caroline.hill@cancer.org.uk
www.london-research-institute.org.uk/research/caroline-hill

Phone:  +44 (0) 20 7269 2941
Fax:  +44 (0) 20 7269 3093

Research Description

The work of my laboratory focuses on the Transforming Growth Factor Beta (TGF-Beta) superfamily, a group of growth and differentiation factors comprising the TGF-Betas, Activins, Nodals, BMPs and GDFs. These ligands play critical roles during early vertebrate development in the specification and subsequent patterning of the germ layers, and deregulation of TGF-Beta, BMP and Nodal signalling has been implicated in cancer. We want to understand the mechanism whereby these ligands signal from the plasma membrane to the nucleus and how they regulate transcription of target genes via activated complexes of Smad proteins. We want to determine how they function and are regulated in embryonic development, and how their activity is perturbed in cancer.

Lab Memberships

Hill Lab (Principal Investigator/Director)
British Xenopus Group (Other)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556