Tom D. Sargent
The focus of our group is on ectodermal development, especially on epidermis and neural crest and the relationship between these two derivatives. Our primary animal model system is the frog Xenopus laevis, but we also work with zebrafish. Microarray analysis of Xenopus ectodermal cells in which the transcription factor AP2alpha has been manipulated resulted in the identification of many regulatory targets for this factor, including genes expressed in epidermis and in the neural crest. The long term goal of the lab is to understand the regulation of such genes and how they function in early embryonic development and in disease.
Lab MembershipsSargent Lab (Principal Investigator/Director)
Section on Vertebrate Development
Laboratory of Molecular Genetics
Bldg 6B Rm 412
6 Center Drive MSC 2790
Fax: 301 496 0243