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Profile Publications(75)
XB-PERS-683

Sergei Y. Sokol

Professor

Department of Developmental & Regenerative Biology
Mount Sinai School of Medicine
Anbg 25-86, Box 1020
One Gustave L. Levy Place
New York, NY
10029, USA

sergei.sokol@mssm.edu
http://research.mssm.edu/sokol/Sokol_lab/

Phone:  617 667 3894

Research Description

Using a number of biochemical, genetic, cell biological and embryological approaches in Xenopus and mouse embryos and mammalian tissue culture cells, we are addressing the following questions:

How is the top of an epithelial cell different from its bottom? Can the same mechanisms that control cell polarity be involved in the regulation of embryo polarity, culminating in the conserved 'head-to-toe' body plan?

How do extracellular growth factors regulate cell polarity and shape of individual cells composing a tissue?

What are the determinants of asymmetric cell divisions? How is mitotic spindle orientation determined in neural progenitor cells?

What is the molecular difference between the front and the back of a migrating cell? How can cell movement be stimulated during wound healing and prevented in metastatic cancer?

Lab Memberships

Sokol Lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556