Lyle ZimmermanNational Institute for Medical Research
We are developing the amphibian Xenopus tropicalis as a model in which vertebrate gene function can be approached with combinations of loss-of-function, gain-of-function, and embryological techniques. Another member of the genus, X. laevis, has been a highly productive model system in cell and developmental biology due to the ease of molecular and surgical manipulations of its embryos, but its complex pseudotetraploid genome and relatively long generation time have precluded genetic approaches. Another important vertebrate genetic model system, the zebrafish, also possesses a complex genome as a result of an ancestral genome duplication. With the potential to combine classical embryological approaches with genetic and transgenic tools in a single model system, X. tropicalis is uniquely positioned to contribute to the functional interpretation of the vertebrate genome.
Lab MembershipsZimmerman Lab (Principal Investigator/Director)
British Xenopus Group (Other)