Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Profile Publications(29)
XB-PERS-960

Michael J. Gilchrist

Position

Research Scientist (retired)

Research Description

Mike Gilchrist's research focussed on gene regulatory networks in early development. The Gilchrist lab was mix of experimental and computational scientists.

They were interested in the early stages of vertebrate development, and studied this at a systems level, using a combination of experimental data and computational techniques in both Xenopus and mouse models. their latest work was in Xenopus, an ideal model system, as many hundreds of developmentally synchronized embryos can be generated from a single clutch.
In addition, the early embryonic axes can be readily identified shortly after fertilization, facilitating the study of axial asymmetry and growth. 
Embryonic development is a complex and tightly controlled process, with a remarkably precise outcome. The underlying control system is only partly understood. Typically, transcription factors regulate the expression of individual genes, and the many relationships between transcription factors and their target genes combine to make gene regulatory networks. Their aim was to elucidate these networks using molecular and computational tools to enable a systematic and large-scale approach, with the goalof understanding development as a series of genetic interactions which need to proceed with the correct timing and in the right location within the growing embryo.


Contact

Address:
The Francis Crick Institute
London
United Kingdom

Phone:  (44) 208 816 2451
Fax:  (44) 208 906 4477


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.2
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556