Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Profile Publications(0)
XB-PERS-1999

Dr.  Aga A. Gambus

Postdoc

School of Cancer Sciences
University of Birmingham
Vincent Drive
Edgbaston
Birmingham
B15 2TT, United Kingdom

a.gambus@bham.ac.uk

Phone:  01214147984

Research Description

I have been working in Professor Julian Blow’s laboratory at the Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee. During this time I acquired experience in working with the Xenopus laevis egg extract system. Using this system, I showed that inactive core of replicative helicase (Mcm2-7 complex) is loaded onto origins of replication in the form of double hexamers, in agreement with data from a budding yeast in vitro reconstitution system. These results suggest that an Mcm2-7 double hexamer can initiate a bidirectional pair of forks during S phase, explaining one of the fundamental rules of DNA replication.

Recently, I moved to School of Cancer Sciences at the University of Birmingham where I started to pursue my independent research

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556