Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Profile Publications(13)
XB-PERS-2109

Dr.  Judith L. Campbell

Professor of Chemistry and Biology

Division of Biology and Biological Engineering
Caltech
Pasadena, CA
USA

jcampbel@caltech.edu
https://www.bbe.caltech.edu/content/judith-l-campbell

Research Description

Mechanisms and Regulation of DNA Replication and Repair

The Campbell Group studies DNA replication in the yeast Saccharomyces cerevisiae. Yeast offers an as yet unparalleled ability to combine genetic, molecular, and biochemical approaches in a eukaryotic organism. In the past, biochemistry has focused on the characterization of individual proteins. In modern biochemistry, the emphasis is on studying protein/protein interactions in multienzyme assemblies. In keeping with this trend, our overall goal is to reproduce the assembly and activation of the replication fork at an origin of replication using purified proteins. Our work in preparation for achieving this goal has ranged from defining the structure and activity of chromosomal replication origins, to the discovery of replicative enzymes, verification of their in vivo roles using yeast genetics, and the detailed characterization of their enzymatic mechanisms.

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556