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Profile Publications(22)
XB-PERS-3507

Shan Yan

Associate Professor

University of North Carolina at Charlotte
9201 University City Blvd
Charlotte, NC
28223, USA

shan.yan@uncc.edu
https://clas-pages.uncc.edu/shan-yan/

Phone:  704-687-8528

Research Description

Molecular Mechanisms of Genomic Integrity Maintenance and Tumorigenesis

Key words: Cancer Biology, Cell Biology, Molecular Biology, Developmental Biology, Environmental Health, Xenopus laevis.

All eukaryotes have evolved an elaborate network, DNA damage response (DDR), to detect aberrant DNA structures or stalled replication forks, and to coordinate DNA repair, checkpoint activation, cell cycle arrest, and senescence/apoptosis. From a broader perspective, the DDR machinery plays important roles in fundamental biomedical fields, such as DNA replication, DNA damage repair, cell cycle regulation, transcription, apoptosis, senescence, and autophogy. Defective DDR pathways compromise genomic integrity, leading to human diseases.
The research projects in the Yan lab focus on several essential questions linking DDR and human diseases, such as cancer, sepsis, aging, and neurodegenerative disorders. Using biochemical, molecular and cell biology approaches, our laboratory is interested in crucial issues in maintaining genomic stability, including checkpoint activation, DNA damage repair, and translesion synthesis (TLS) in response to DNA replication stress and oxidative stress as well as other stressful conditions. Ultimately, our research program will help to better understand how cells maintain genome stability and to provide novel clues for detection and treatment of human diseases. Xenopus egg extracts and mammalian cell lines will be used as model systems to investigate fundamental biomedical questions with cutting-edge technologies. One aim of this lab is to establish a motivated and productive research team. You are welcome to visit and/or join us!
 
Research Projects:

(1) TopBP1-mediated checkpoint signaling in DNA replication stress response
(2) Molecular mechanisms of DNA damage response pathway in oxidative stress
(3) Single-strand break repair and signaling
(4) Translesion DNA synthesis and DNA damage response
(5) DNA repair and DNA damage response pathways in human diseases (cancer, sepsis, aging, and neurodegenerative diseases)

Lab Memberships

The Yan Lab (Principal Investigator/Director)

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556