Professor, Department of Oncological StudiesHuntsman Cancer Institute
2000 Circle of Hope
Salt Lake City, UT
Nuclear Pore Complexes; Nup153; Molecular Mechanisms; Pore and Envelope Disassembly; Cell Division; Structure-Function Analysis; The Tumor Suppressor PDCD4. We are interested in how dispersal and reformation of the nuclear envelope is carried out during cell division and how this morphological remodeling is coordinated with other cell cycle events. We also study a protein partnership we discovered between PDCD4 and PRMT5. We have shown that these two proteins are useful when combined as a biomarker signature and now aim to unlock the mechanistic pathway underlying their collaboration in tumor growth. These projects are focused on fundamental aspects of cell biology with the overarching goal of revealing how cell function is deregulated in cancer and identifying new strategies to block cancerous cell growth.
Lab MembershipsUllman Lab (Principal Investigator/Director)