2016 Xenopus White Paper

Dear Xenopus Community,

The 2016 Xenopus Community White Paper is finished as prepared by Sally Moody and Amy Sater.

Its contents are based on discussions from the 2015 PIs Meeting at Woods Hole:

Executive Summary:

    Xenopus is an essential vertebrate model system for biomedical research
    Past NIH investment in research using Xenopus has advanced biomedical research
    Community recommendations for continued NIH investment in Xenopus research
    Long term goals of using Xenopus for biomedical research

Xenopus is an essential vertebrate model sysytem for:

    Understanding fundamental biological processes
    Applying fundamental knowledge to pathological processes
    Deciphering the function of human disease genes
    Modeling human diseases

Recommendations for Continued NIH Investment in Xenopus Research:

    Immediate Needs
        Development of Protein Resources (ORFeome; Antibodies; Proteome)
        Development of Big Data Repositories (Xenbase, XenMine)

    Essential resources:
        Enhancement of Efficient Gene Editing Approaches and Mutant Lines
        Enhancement of Transgenic Resources
        Improvement and Expansion of Amphibian Genomic Resources
        Support for Xenopus Training and Meetings

Long Term Goal of Using Xenopus to Understand Human Disease

Download the 2016 Xenopus Community White Paper:

     Word Document

     PDF

PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

Authors:

    Sally A. Moody
    Amy K. Sater

Contributors:

    Dominique Alfandari
    Julie Baker
    Ira Blitz
    Ben Evans
    Mike Gilchrist
    Marko Horb
    Aldo Ciau-Uitz
    Darcy Kelley
    Takuya Nakayama
    Christine Reid
    Jacques Robert
    Todd Stukenberg
    Martin Wuehr
    Aaron Zorn