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Summary Expression Phenotypes Gene Literature (129) GO Terms (7) Nucleotides (158) Proteins (40) Interactants (599) Wiki
XB--5995151

Papers associated with smad4.2



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Identification of two Smad4 proteins in Xenopus. Their common and distinct properties., Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E., J Biol Chem. April 23, 1999; 274 (17): 12163-70.                

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus., Hoodless PA, Tsukazaki T, Nishimatsu S, Attisano L, Wrana JL, Thomsen GH., Dev Biol. March 15, 1999; 207 (2): 364-79.

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3., Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K., J Biol Chem. January 8, 1999; 274 (2): 703-9.

FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals., Liu B, Dou CL, Prabhu L, Lai E., Mol Cell Biol. January 1, 1999; 19 (1): 424-30.

Spemann organizer activity of Smad10., LeSueur JA, Graff JM., Development. January 1, 1999; 126 (1): 137-46.

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor., Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL., Cell. December 11, 1998; 95 (6): 779-91.

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis., Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M., Mech Dev. December 1, 1998; 79 (1-2): 17-27.        

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2., Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL., J Biol Chem. October 2, 1998; 273 (40): 25628-36.

Smad3 mutant mice develop metastatic colorectal cancer., Zhu Y, Richardson JA, Parada LF, Graff JM., Cell. September 18, 1998; 94 (6): 703-14.

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2., Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX., Proc Natl Acad Sci U S A. August 4, 1998; 95 (16): 9378-83.

Characterization of human FAST-1, a TGF beta and activin signal transducer., Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B., Mol Cell. July 1, 1998; 2 (1): 121-7.

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2., Labbé E, Silvestri C, Hoodless PA, Wrana JL, Attisano L., Mol Cell. July 1, 1998; 2 (1): 109-20.

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells., Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B., Proc Natl Acad Sci U S A. March 3, 1998; 95 (5): 2412-6.

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line., Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K., Genes Cells. February 1, 1998; 3 (2): 125-34.

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor., Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A., Genes Dev. January 15, 1998; 12 (2): 186-97.          

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes., Liu F, Pouponnot C, Massagué J., Genes Dev. December 1, 1997; 11 (23): 3157-67.

Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase., Chen Y, Bhushan A, Vale W., Proc Natl Acad Sci U S A. November 25, 1997; 94 (24): 12938-43.          

Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads., Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW., Development. November 1, 1997; 124 (22): 4467-80.

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling., Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P., Nature. October 9, 1997; 389 (6651): 631-5.

Smad4 and FAST-1 in the assembly of activin-responsive factor., Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M., Nature. September 4, 1997; 389 (6646): 85-9.

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4., Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P., EMBO J. September 1, 1997; 16 (17): 5353-62.

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4., Hata A, Lo RS, Wotton D, Lagna G, Massagué J., Nature. July 3, 1997; 388 (6637): 82-7.

Smad5 induces ventral fates in Xenopus embryo., Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A., Dev Biol. April 15, 1997; 184 (2): 402-5.    

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function., Zhang Y, Musci T, Derynck R., Curr Biol. April 1, 1997; 7 (4): 270-6.

Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway., Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P., J Biol Chem. January 31, 1997; 272 (5): 2896-900.

Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer., Moskaluk CA, Kern SE., Biochim Biophys Acta. December 9, 1996; 1288 (3): M31-3.

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways., Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J., Nature. October 31, 1996; 383 (6603): 832-6.

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma., Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L., Cell. August 23, 1996; 86 (4): 543-52.

A human Mad protein acting as a BMP-regulated transcriptional activator., Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J., Nature. June 13, 1996; 381 (6583): 620-3.

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