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Summary Expression Phenotypes Gene Literature (192) GO Terms (6) Nucleotides (126) Proteins (56) Interactants (656) Wiki
XB--487965

Papers associated with nkx2-5



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Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart., Toko H, Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I., J Biol Chem. July 5, 2002; 277 (27): 24735-43.

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5., Wakimoto H, Kasahara H, Maguire CT, Izumo S, Berul CI., J Cardiovasc Electrophysiol. July 1, 2002; 13 (7): 682-8.

The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis., Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y., J Clin Invest. July 1, 2002; 110 (2): 177-84.

Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor., Müller JG, Thompson JT, Edmonson AM, Rackley MS, Kasahara H, Izumo S, McQuinn TC, Menick DR, O'Brien TX., J Mol Cell Cardiol. July 1, 2002; 34 (7): 807-21.

A role for the RNA-binding protein, hermes, in the regulation of heart development., Gerber WV, Vokes SA, Zearfoss NR, Krieg PA., Dev Biol. July 1, 2002; 247 (1): 116-26.    

Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease., Ikeda Y, Hiroi Y, Hosoda T, Utsunomiya T, Matsuo S, Ito T, Inoue J, Sumiyoshi T, Takano H, Nagai R, Komuro I., Circ J. June 1, 2002; 66 (6): 561-3.

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation., Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM., Genes Dev. May 15, 2002; 16 (10): 1234-46.

Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site., Lien CL, McAnally J, Richardson JA, Olson EN., Dev Biol. April 15, 2002; 244 (2): 257-66.

Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region., Liberatore CM, Searcy-Schrick RD, Vincent EB, Yutzey KE., Dev Biol. April 15, 2002; 244 (2): 243-56.

A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5., Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S., Cold Spring Harb Symp Quant Biol. January 1, 2002; 67 317-25.

Homeodomain factor Nkx2-5 in heart development and disease., Harvey RP, Lai D, Elliott D, Biben C, Solloway M, Prall O, Stennard F, Schindeler A, Groves N, Lavulo L, Hyun C, Yeoh T, Costa M, Furtado M, Kirk E., Cold Spring Harb Symp Quant Biol. January 1, 2002; 67 107-14.

Developmental paradigms in heart disease: insights from tinman., Prall OW, Elliott DA, Harvey RP., Ann Med. January 1, 2002; 34 (3): 148-56.

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice., Moses KA, DeMayo F, Braun RM, Reecy JL, Schwartz RJ., Genesis. December 1, 2001; 31 (4): 176-80.

BMP signaling regulates Nkx2-5 activity during cardiomyogenesis., Jamali M, Karamboulas C, Rogerson PJ, Skerjanc IS., FEBS Lett. November 30, 2001; 509 (1): 126-30.

NKX2.5 mutations in patients with tetralogy of fallot., Goldmuntz E, Geiger E, Benson DW., Circulation. November 20, 2001; 104 (21): 2565-8.

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation., Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D., Dev Biol. November 15, 2001; 239 (2): 190-203.

Nkx2-5 activity is essential for cardiomyogenesis., Jamali M, Rogerson PJ, Wilton S, Skerjanc IS., J Biol Chem. November 9, 2001; 276 (45): 42252-8.

Endoderm specification and differentiation in Xenopus embryos., Horb ME, Slack JM., Dev Biol. August 15, 2001; 236 (2): 330-43.                

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein., Kasahara H, Wakimoto H, Liu M, Maguire CT, Converso KL, Shioi T, Huang WY, Manning WJ, Paul D, Lawitts J, Berul CI, Izumo S., J Clin Invest. July 1, 2001; 108 (2): 189-201.

Elevated expression of Nkx-2.5 in developing myocardial conduction cells., Thomas PS, Kasahara H, Edmonson AM, Izumo S, Yacoub MH, Barton PJ, Gourdie RG., Anat Rec. July 1, 2001; 263 (3): 307-13.

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation., Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I., Nat Genet. July 1, 2001; 28 (3): 276-80.

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx., Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S., Mol Cell Biol. July 1, 2001; 21 (13): 4391-8.

Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5., Reiter JF, Verkade H, Stainier DY., Dev Biol. June 15, 2001; 234 (2): 330-8.

Twisted gastrulation can function as a BMP antagonist., Chang C, Holtzman DA, Chau S, Chickering T, Woolf EA, Holmgren LM, Bodorova J, Gearing DP, Holmes WE, Brivanlou AH., Nature. March 22, 2001; 410 (6827): 483-7.

Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein., Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S., J Biol Chem. February 16, 2001; 276 (7): 4570-80.

Inhibition of Wnt activity induces heart formation from posterior mesoderm., Marvin MJ, Di Rocco G, Gardiner A, Bush SM, Lassar AB., Genes Dev. February 1, 2001; 15 (3): 316-27.  

COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development., Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M., J Biol Chem. January 26, 2001; 276 (4): 2797-801.

Factors in serum regulate Nkx2.5 and MEF2C function., Jamali M, Karamboulas C, Wilton S, Skerjanc IS., In Vitro Cell Dev Biol Anim. January 1, 2001; 37 (10): 635-7.

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5., Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott DA, Barnett L, Köentgen F, Robb L, Feneley M, Harvey RP., Circ Res. November 10, 2000; 87 (10): 888-95.

Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease., Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I., J Biol Chem. November 10, 2000; 275 (45): 35291-6.

Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis., Hollemann T, Pieler T., Dev Genes Evol. November 1, 2000; 210 (11): 579-81.

Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning., Bradley L, Sun B, Collins-Racie L, LaVallie E, McCoy J, Sive H., Dev Biol. November 1, 2000; 227 (1): 118-32.                    

Regulation of the tinman homologues in Xenopus embryos., Sparrow DB, Cai C, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ., Dev Biol. November 1, 2000; 227 (1): 65-79.      

Designation of the anterior/posterior axis in pregastrula Xenopus laevis., Lane MC, Sheets MD., Dev Biol. September 1, 2000; 225 (1): 37-58.                        

Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis., Rones MS, McLaughlin KA, Raffin M, Mercola M., Development. September 1, 2000; 127 (17): 3865-76.                  

Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary., Smith DM, Nielsen C, Tabin CJ, Roberts DJ., Development. September 1, 2000; 127 (17): 3671-81.

BMP signaling is required for heart formation in vertebrates., Shi Y, Shi Y, Katsev S, Cai C, Evans S., Dev Biol. August 15, 2000; 224 (2): 226-37.          

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease., Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S., J Clin Invest. July 1, 2000; 106 (2): 299-308.

Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice., Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, Hiroi Y, Oka T, Hayashi D, Hirai H, Kudoh S, Toko H, Kawamura K, Nagai R, Yazaki Y, Komuro I., Biochem Biophys Res Commun. April 21, 2000; 270 (3): 1074-9.

Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10., Newman CS, Reecy J, Grow MW, Ni K, Boettger T, Kessel M, Schwartz RJ, Krieg PA., Mech Dev. March 1, 2000; 91 (1-2): 369-73.  

Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments., Raffin M, Leong LM, Rones MS, Sparrow D, Mohun T, Mercola M., Dev Biol. February 15, 2000; 218 (2): 326-40.                  

The morphology of heart development in Xenopus laevis., Mohun TJ, Leong LM, Weninger WJ, Sparrow DB., Dev Biol. February 1, 2000; 218 (1): 74-88.                    

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart., Molkentin JD, Antos C, Mercer B, Taigen T, Miano JM, Olson EN., Dev Biol. January 15, 2000; 217 (2): 301-9.

Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand., Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE., Dev Biol. January 15, 2000; 217 (2): 266-77.  

A role for GATA-4/5/6 in the regulation of Nkx2.5 expression with implications for patterning of the precardiac field., Jiang Y, Drysdale TA, Evans T., Dev Biol. December 1, 1999; 216 (1): 57-71.            

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways., Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD., J Clin Invest. December 1, 1999; 104 (11): 1567-73.

Gata5 is required for the development of the heart and endoderm in zebrafish., Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY., Genes Dev. November 15, 1999; 13 (22): 2983-95.

Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4., Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, Hayashi D, Hosoda T, Habara-Ohkubo A, Nakaoka T, Fujita T, Yazaki Y, Komuro I., Mol Cell Biol. October 1, 1999; 19 (10): 7096-105.

Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription., Schwartz RJ, Olson EN., Development. October 1, 1999; 126 (19): 4187-92.

Amphibian embryos as a model system for organ engineering: in vitro induction and rescue of the heart anlage., Grunz H., Int J Dev Biol. July 1, 1999; 43 (4): 361-4.        

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