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Summary Expression Phenotypes Gene Literature (192) GO Terms (6) Nucleotides (126) Proteins (56) Interactants (656) Wiki
XB--487965

Papers associated with nkx2-5



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Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation., Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I., Nat Genet. July 1, 2001; 28 (3): 276-80.

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx., Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S., Mol Cell Biol. July 1, 2001; 21 (13): 4391-8.

Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5., Reiter JF, Verkade H, Stainier DY., Dev Biol. June 15, 2001; 234 (2): 330-8.

Twisted gastrulation can function as a BMP antagonist., Chang C, Holtzman DA, Chau S, Chickering T, Woolf EA, Holmgren LM, Bodorova J, Gearing DP, Holmes WE, Brivanlou AH., Nature. March 22, 2001; 410 (6827): 483-7.

Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein., Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S., J Biol Chem. February 16, 2001; 276 (7): 4570-80.

Inhibition of Wnt activity induces heart formation from posterior mesoderm., Marvin MJ, Di Rocco G, Gardiner A, Bush SM, Lassar AB., Genes Dev. February 1, 2001; 15 (3): 316-27.  

COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development., Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M., J Biol Chem. January 26, 2001; 276 (4): 2797-801.

Factors in serum regulate Nkx2.5 and MEF2C function., Jamali M, Karamboulas C, Wilton S, Skerjanc IS., In Vitro Cell Dev Biol Anim. January 1, 2001; 37 (10): 635-7.

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5., Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott DA, Barnett L, Köentgen F, Robb L, Feneley M, Harvey RP., Circ Res. November 10, 2000; 87 (10): 888-95.

Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease., Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I., J Biol Chem. November 10, 2000; 275 (45): 35291-6.

Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis., Hollemann T, Pieler T., Dev Genes Evol. November 1, 2000; 210 (11): 579-81.

Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning., Bradley L, Sun B, Collins-Racie L, LaVallie E, McCoy J, Sive H., Dev Biol. November 1, 2000; 227 (1): 118-32.                    

Regulation of the tinman homologues in Xenopus embryos., Sparrow DB, Cai C, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ., Dev Biol. November 1, 2000; 227 (1): 65-79.      

Designation of the anterior/posterior axis in pregastrula Xenopus laevis., Lane MC, Sheets MD., Dev Biol. September 1, 2000; 225 (1): 37-58.                        

Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis., Rones MS, McLaughlin KA, Raffin M, Mercola M., Development. September 1, 2000; 127 (17): 3865-76.                  

Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary., Smith DM, Nielsen C, Tabin CJ, Roberts DJ., Development. September 1, 2000; 127 (17): 3671-81.

BMP signaling is required for heart formation in vertebrates., Shi Y, Shi Y, Katsev S, Cai C, Evans S., Dev Biol. August 15, 2000; 224 (2): 226-37.          

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease., Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S., J Clin Invest. July 1, 2000; 106 (2): 299-308.

Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice., Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, Hiroi Y, Oka T, Hayashi D, Hirai H, Kudoh S, Toko H, Kawamura K, Nagai R, Yazaki Y, Komuro I., Biochem Biophys Res Commun. April 21, 2000; 270 (3): 1074-9.

Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10., Newman CS, Reecy J, Grow MW, Ni K, Boettger T, Kessel M, Schwartz RJ, Krieg PA., Mech Dev. March 1, 2000; 91 (1-2): 369-73.  

Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments., Raffin M, Leong LM, Rones MS, Sparrow D, Mohun T, Mercola M., Dev Biol. February 15, 2000; 218 (2): 326-40.                  

The morphology of heart development in Xenopus laevis., Mohun TJ, Leong LM, Weninger WJ, Sparrow DB., Dev Biol. February 1, 2000; 218 (1): 74-88.                    

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart., Molkentin JD, Antos C, Mercer B, Taigen T, Miano JM, Olson EN., Dev Biol. January 15, 2000; 217 (2): 301-9.

Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand., Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE., Dev Biol. January 15, 2000; 217 (2): 266-77.  

A role for GATA-4/5/6 in the regulation of Nkx2.5 expression with implications for patterning of the precardiac field., Jiang Y, Drysdale TA, Evans T., Dev Biol. December 1, 1999; 216 (1): 57-71.            

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways., Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD., J Clin Invest. December 1, 1999; 104 (11): 1567-73.

Gata5 is required for the development of the heart and endoderm in zebrafish., Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY., Genes Dev. November 15, 1999; 13 (22): 2983-95.

Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4., Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, Hayashi D, Hosoda T, Habara-Ohkubo A, Nakaoka T, Fujita T, Yazaki Y, Komuro I., Mol Cell Biol. October 1, 1999; 19 (10): 7096-105.

Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription., Schwartz RJ, Olson EN., Development. October 1, 1999; 126 (19): 4187-92.

Amphibian embryos as a model system for organ engineering: in vitro induction and rescue of the heart anlage., Grunz H., Int J Dev Biol. July 1, 1999; 43 (4): 361-4.        

Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice., Saadane N, Alpert L, Chalifour LE., Br J Pharmacol. July 1, 1999; 127 (5): 1165-76.

Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5., Rivkees SA, Chen M, Kulkarni J, Browne J, Zhao Z., J Biol Chem. May 14, 1999; 274 (20): 14204-9.

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site., Amendt BA, Sutherland LB, Russo AF., J Biol Chem. April 23, 1999; 274 (17): 11635-42.

Tbx5 is essential for heart development., Horb ME, Thomsen GH., Development. April 1, 1999; 126 (8): 1739-51.              

Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5., Tanaka M, Wechsler SB, Lee IW, Yamasaki N, Lawitts JA, Izumo S., Development. April 1, 1999; 126 (7): 1439-50.

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development., Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S., Development. March 1, 1999; 126 (6): 1269-80.

Seeking a regulatory roadmap for heart morphogenesis., Harvey RP., Semin Cell Dev Biol. February 1, 1999; 10 (1): 99-107.

Vertebrate tinman homologues and cardiac differentiation., Evans SM., Semin Cell Dev Biol. February 1, 1999; 10 (1): 73-83.

Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5., Reecy JM, Li X, Yamada M, DeMayo FJ, Newman CS, Harvey RP, Schwartz RJ., Development. February 1, 1999; 126 (4): 839-49.

Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5., Kasahara H, Izumo S., Mol Cell Biol. January 1, 1999; 19 (1): 526-36.

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer., Lien CL, Wu C, Mercer B, Webb R, Richardson JA, Olson EN., Development. January 1, 1999; 126 (1): 75-84.

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5., Grow MW, Krieg PA., Dev Biol. December 1, 1998; 204 (1): 187-96.      

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice., Searcy RD, Vincent EB, Liberatore CM, Yutzey KE., Development. November 1, 1998; 125 (22): 4461-70.

Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner., Fu Y, Yan W, Mohun TJ, Evans SM., Development. November 1, 1998; 125 (22): 4439-49.            

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice., Ranganayakulu G, Elliott DA, Harvey RP, Olson EN., Development. August 1, 1998; 125 (16): 3037-48.

Congenital heart disease caused by mutations in the transcription factor NKX2-5., Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG., Science. July 3, 1998; 281 (5373): 108-11.

GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression., Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ., Mol Cell Biol. June 1, 1998; 18 (6): 3405-15.

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule., Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, Lah M, Wang CC, Nash A, Hilton D, Ang SL, Mohun T, Harvey RP., Dev Biol. February 15, 1998; 194 (2): 135-51.    

Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development., Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE, Izumo S., Dev Genet. January 1, 1998; 22 (3): 239-49.

tinman-related genes expressed during heart development in Xenopus., Newman CS, Krieg PA., Dev Genet. January 1, 1998; 22 (3): 230-8.  

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