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Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. , Lien CL, Wu C , Mercer B, Webb R, Richardson JA, Olson EN., Development. January 1, 1999; 126 (1): 75-84.
Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. , Grow MW , Krieg PA ., Dev Biol. December 1, 1998; 204 (1): 187-96.
A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. , Searcy RD, Vincent EB, Liberatore CM, Yutzey KE., Development. November 1, 1998; 125 (22): 4461-70.
Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. , Fu Y, Yan W, Mohun TJ , Evans SM., Development. November 1, 1998; 125 (22): 4439-49.
Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. , Ranganayakulu G, Elliott DA, Harvey RP , Olson EN., Development. August 1, 1998; 125 (16): 3037-48.
Congenital heart disease caused by mutations in the transcription factor NKX2-5. , Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG., Science. July 3, 1998; 281 (5373): 108-11.
GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. , Sepulveda JL, Belaguli N, Nigam V, Chen CY , Nemer M, Schwartz RJ., Mol Cell Biol. June 1, 1998; 18 (6): 3405-15.
Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. , Biben C, Stanley E, Fabri L, Kotecha S , Rhinn M, Drinkwater C, Lah M, Wang CC , Nash A, Hilton D , Ang SL, Mohun T, Harvey RP ., Dev Biol. February 15, 1998; 194 (2): 135-51.
Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. , Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y , Lyons GE, Izumo S., Dev Genet. January 1, 1998; 22 (3): 239-49.
tinman-related genes expressed during heart development in Xenopus. , Newman CS, Krieg PA ., Dev Genet. January 1, 1998; 22 (3): 230-8.
Homeobox genes in cardiovascular development. , Patterson KD , Cleaver O, Gerber WV , Grow MW , Newman CS, Krieg PA ., Curr Top Dev Biol. January 1, 1998; 40 1-44.
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. , Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M., EMBO J. September 15, 1997; 16 (18): 5687-96.
Retinoic acid can block differentiation of the myocardium after heart specification. , Drysdale TA , Patterson KD , Saha M , Krieg PA ., Dev Biol. August 15, 1997; 188 (2): 205-15.
Homeodomain factor Nkx2-5 controls left/ right asymmetric expression of bHLH gene eHand during murine heart development. , Biben C, Harvey RP ., Genes Dev. June 1, 1997; 11 (11): 1357-69.
Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity. , Chen CY , Schwartz RJ., Mol Endocrinol. June 1, 1997; 11 (6): 812-22.
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. , Zou Y, Evans S, Chen J , Kuo HC, Harvey RP , Chien KR., Development. February 1, 1997; 124 (4): 793-804.
Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors. , Gove C, Walmsley M, Nijjar S, Bertwistle D, Guille M , Partington G, Bomford A, Patient R ., EMBO J. January 15, 1997; 16 (2): 355-68.
Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle. , Newman CS, Grow MW , Cleaver O , Chia F, Krieg P ., Dev Biol. January 15, 1997; 181 (2): 223-33.
A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. , Lee KH, Xu Q, Breitbart RE., Dev Biol. December 15, 1996; 180 (2): 722-31.
Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. , Chen JN , Fishman MC., Development. December 1, 1996; 122 (12): 3809-16.
Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. , Cleaver OB , Patterson KD , Krieg PA ., Development. November 1, 1996; 122 (11): 3549-56.
Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. , Chen CY , Schwartz RJ., Mol Cell Biol. November 1, 1996; 16 (11): 6372-84.
The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. , Durocher D, Chen CY , Ardati A, Schwartz RJ, Nemer M., Mol Cell Biol. September 1, 1996; 16 (9): 4648-55.
Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development. , Buchberger A, Pabst O, Brand T, Seidl K, Arnold HH., Mech Dev. May 1, 1996; 56 (1-2): 151-63.
Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx. , Turbay D, Wechsler SB, Blanchard KM, Izumo S., Mol Med. January 1, 1996; 2 (1): 86-96.
Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements. , Chen CY , Croissant J, Majesky M, Topouzis S, McQuinn T, Frankovsky MJ, Schwartz RJ., Dev Genet. January 1, 1996; 19 (2): 119-30.
Induction of avian cardiac myogenesis by anterior endoderm. , Schultheiss TM, Xydas S, Lassar AB., Development. December 1, 1995; 121 (12): 4203-14.
tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. , Evans SM, Yan W, Murillo MP, Ponce J, Papalopulu N ., Development. November 1, 1995; 121 (11): 3889-99.
Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. , Chen CY , Schwartz RJ., J Biol Chem. June 30, 1995; 270 (26): 15628-33.
Assignment of cardiac homeobox gene CSX to human chromosome 5q34. , Shiojima I, Komuro I, Inazawa J, Nakahori Y, Matsushita I, Abe T, Nagai R, Yazaki Y., Genomics. May 1, 1995; 27 (1): 204-6.
High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci. , Himmelbauer H, Harvey RP , Copeland NG, Jenkins NA, Silver LM., Mamm Genome. December 1, 1994; 5 (12): 814-6.
XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. , Tonissen KF , Drysdale TA , Lints TJ, Harvey RP , Krieg PA ., Dev Biol. March 1, 1994; 162 (1): 325-8.