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Summary Expression Phenotypes Gene Literature (94) GO Terms (6) Nucleotides (106) Proteins (50) Interactants (395) Wiki
XB--482110

Papers associated with pkd2



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Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels., Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ., Nat Commun. June 13, 2018; 9 (1): 2302.            

Premotor Neuron Divergence Reflects Vocal Evolution., Barkan CL, Kelley DB, Zornik E., J Neurosci. June 6, 2018; 38 (23): 5325-5337.              

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus., Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M., iScience. April 27, 2018; 2 76-85.                                        

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney., Zhang B, Tran U, Wessely O., Development. March 22, 2018; 145 (6):                         

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2., Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ., Cell Rep. February 6, 2018; 22 (6): 1560-1573.          

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex., Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM., J Am Soc Nephrol. October 1, 2017; 28 (10): 2973-2984.

The polycystin complex mediates Wnt/Ca(2+) signalling., Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L., Nat Cell Biol. July 1, 2016; 18 (7): 752-764.              

Using Xenopus to study genetic kidney diseases., Lienkamp SS., Semin Cell Dev Biol. March 1, 2016; 51 117-24.    

Retigabine holds KV7 channels open and stabilizes the resting potential., Corbin-Leftwich A, Mossadeq SM, Ha J, Ruchala I, Le AH, Villalba-Galea CA., J Gen Physiol. March 1, 2016; 147 (3): 229-41.            

Hereditary Renal Hypouricemia Type 1 and Autosomal Dominant Polycystic Kidney Disease., Stiburkova B, Stekrova J, Nakamura M, Ichida K., Am J Med Sci. October 1, 2015; 350 (4): 268-71.

TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus., Futel M, Leclerc C, Le Bouffant R, Buisson I, Néant I, Umbhauer M, Moreau M, Riou JF., J Cell Sci. March 1, 2015; 128 (5): 888-99.                      

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality., Boskovski MT, Yuan S, Pedersen NB, Goth CK, Makova S, Clausen H, Brueckner M, Khokha MK., Nature. December 19, 2013; 504 (7480): 456-9.    

Left-right asymmetry: lessons from Cancún., Burdine RD, Caspary T., Development. November 1, 2013; 140 (22): 4465-70.    

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation., Streets AJ, Wessely O, Peters DJ, Ong AC., Hum Mol Genet. May 15, 2013; 22 (10): 1924-39.

Angiogenesis in the intermediate lobe of the pituitary gland alters its structure and function., Tanaka S, Nakakura T, Jansen EJ, Unno K, Okada R, Suzuki M, Martens GJ, Kikuyama S., Gen Comp Endocrinol. May 1, 2013; 185 10-8.        

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex., Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J., Nat Commun. January 1, 2012; 3 1252.            

α-TC1.9 cells--a model system for analyzing the endoproteolytic processing of POMC., Chen Q, Layton K, Veo K, Angleson JK, Dores RM., Gen Comp Endocrinol. May 15, 2011; 172 (1): 96-106.

Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein., Duning K, Rosenbusch D, Schlüter MA, Tian Y, Kunzelmann K, Meyer N, Schulze U, Markoff A, Pavenstädt H, Weide T., J Biol Chem. October 29, 2010; 285 (44): 33584-8.

V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells., Jansen EJ, Hafmans TG, Martens GJ., Mol Biol Cell. October 1, 2010; 21 (19): 3330-9.                

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1., Woodward OM, Li Y, Yu S, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F., PLoS One. August 23, 2010; 5 (8): e12305.              

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity., Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O., Development. April 1, 2010; 137 (7): 1107-16.              

Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease., Li Y, Santoso NG, Yu S, Yu S, Woodward OM, Qian F, Guggino WB., J Biol Chem. December 25, 2009; 284 (52): 36431-36441.

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex., Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J., Proc Natl Acad Sci U S A. July 14, 2009; 106 (28): 11558-63.

TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum., Wegierski T, Steffl D, Kopp C, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, Köttgen M., EMBO J. March 4, 2009; 28 (5): 490-9.

Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences., Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology. March 1, 2009; 150 (3): 1393-9.

Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants., Sullivan-Brown J, Schottenfeld J, Okabe N, Hostetter CL, Serluca FC, Thiberge SY, Burdine RD., Dev Biol. February 15, 2008; 314 (2): 261-75.

Cilia-driven leftward flow determines laterality in Xenopus., Schweickert A, Weber T, Beyer T, Vick P, Bogusch S, Feistel K, Blum M., Curr Biol. January 9, 2007; 17 (1): 60-6.        

Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head., Butscheid Y, Chubanov V, Steger K, Meyer D, Dietrich A, Gudermann T., Mol Reprod Dev. March 1, 2006; 73 (3): 350-60.

ScOPT1 and AtOPT4 function as proton-coupled oligopeptide transporters with broad but distinct substrate specificities., Osawa H, Stacey G, Gassmann W., Biochem J. January 1, 2006; 393 (Pt 1): 267-75.

Inhibition of polycystin-L channel by the Chinese herb Sparganum stoloniferum Buch.-Ham., Li F, Dai XQ, Li Q, Wu Y, Chen XZ., Can J Physiol Pharmacol. January 1, 2006; 84 (8-9): 923-7.

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling., Li Y, Wright JM, Qian F, Germino GG, Guggino WB., J Biol Chem. December 16, 2005; 280 (50): 41298-306.

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis., Bisgrove BW, Snarr BS, Emrazian A, Yost HJ., Dev Biol. November 15, 2005; 287 (2): 274-88.

Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry., Qiu D, Cheng SM, Wozniak L, McSweeney M, Perrone E, Levin M., Dev Dyn. September 1, 2005; 234 (1): 176-89.      

Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells., Shin JB, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gründer S., Proc Natl Acad Sci U S A. August 30, 2005; 102 (35): 12572-7.              

Cloning and expression of the amphibian homologue of the human PKD1 gene., Burtey S, Leclerc C, Nabais E, Munch P, Gohory C, Moreau M, Fontés M., Gene. August 29, 2005; 357 (1): 29-36.          

Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes., Chernova MN, Vandorpe DH, Clark JS, Alper SL., Kidney Int. August 1, 2005; 68 (2): 632-41.

Expression of proopiomelanocortin and its cleavage enzyme genes in Rana esculenta and Xenopus laevis gonads., Carotti M, Nabissi M, Mosconi G, Gangnon F, Lihrmann I, Vaudry H, Polzonetti-Magni AM., Ann N Y Acad Sci. April 1, 2005; 1040 261-3.

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney., Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N., Development. August 1, 2004; 131 (16): 4085-93.

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization., Cano DA, Murcia NS, Pazour GJ, Hebrok M., Development. July 1, 2004; 131 (14): 3457-67.

Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel., Venglarik CJ, Gao Z, Lu X., J Am Soc Nephrol. May 1, 2004; 15 (5): 1168-77.

Left-right asymmetry: nodal points., Mercola M., J Cell Sci. August 15, 2003; 116 (Pt 16): 3251-7.      

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia., Luo Y, Vassilev PM, Li X, Kawanabe Y, Zhou J., Mol Cell Biol. April 1, 2003; 23 (7): 2600-7.

Polycystin-2 associates with tropomyosin-1, an actin microfilament component., Li Q, Dai Y, Guo L, Liu Y, Hao C, Wu G, Basora N, Michalak M, Chen XZ., J Mol Biol. January 31, 2003; 325 (5): 949-62.

Polycystin-2 interacts with troponin I, an angiogenesis inhibitor., Li Q, Shen PY, Wu G, Chen XZ., Biochemistry. January 21, 2003; 42 (2): 450-7.

Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis., Vandorpe DH, Wilhelm S, Jiang L, Ibraghimov-Beskrovnaya O, Chernova MN, Stuart-Tilley AK, Alper SL., Physiol Genomics. February 28, 2002; 8 (2): 87-98.

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X., Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev PM, Brown EM, Hediger MA, Zhou J., Biochem Biophys Res Commun. April 20, 2001; 282 (5): 1251-6.

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease., Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Ye Cp, Brown EM, Hediger MA, Zhou J., Biochem Biophys Res Commun. March 23, 2001; 282 (1): 341-50.

Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins., Schoonderwoert VT, Holthuis JC, Tanaka S, Tooze SA, Martens GJ., Eur J Biochem. September 1, 2000; 267 (17): 5646-54.

Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development., Holling TM, van Herp F, Durston AJ, Martens GJ., Brain Res Mol Brain Res. January 10, 2000; 75 (1): 70-5.      

Polycystin-L is a calcium-regulated cation channel permeable to calcium ions., Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J., Nature. September 23, 1999; 401 (6751): 383-6.

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