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Summary Expression Phenotypes Gene Literature (106) GO Terms (4) Nucleotides (57) Proteins (33) Interactants (107) Wiki
XB--1010661

Papers associated with kcna1



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Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Nilsson J, Madeja M, Arhem P., Mol Pharmacol. June 1, 2003; 63 (6): 1417-29.

Early embryonic expression of ion channels and pumps in chick and Xenopus development., Rutenberg J, Cheng SM, Levin M., Dev Dyn. December 1, 2002; 225 (4): 469-84.                            

Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel., Michaelevski I, Chikvashvili D, Tsuk S, Fili O, Lohse MJ, Singer-Lahat D, Lotan I., J Biol Chem. September 20, 2002; 277 (38): 34909-17.

Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivation., Maylie B, Bissonnette E, Virk M, Adelman JP, Maylie JG., J Neurosci. June 15, 2002; 22 (12): 4786-93.

Characteristics of brain Kv1 channels tailored to mimic native counterparts by tandem linkage of alpha subunits: implications for K+ channelopathies., Akhtar S, Shamotienko O, Papakosta M, Ali F, Dolly JO., J Biol Chem. May 10, 2002; 277 (19): 16376-82.

Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2)., McCormack K, Connor JX, Zhou L, Ho LL, Ganetzky B, Chiu SY, Messing A., J Biol Chem. April 12, 2002; 277 (15): 13219-28.

Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1., Rea R, Spauschus A, Eunson LH, Hanna MG, Kullmann DM., J Physiol. January 1, 2002; 538 (Pt 1): 5-23.

Functional and molecular expression of a voltage-dependent K(+) channel (Kv1.1) in interstitial cells of Cajal., Hatton WJ, Mason HS, Carl A, Doherty P, Latten MJ, Kenyon JL, Sanders KM, Horowitz B., J Physiol. June 1, 2001; 533 (Pt 2): 315-27.

Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes., Hinck D, Wulff H, Koppenhöfer E., Gen Physiol Biophys. March 1, 2001; 20 (1): 83-95.

Expression cloning of KCRF, a potassium channel regulatory factor., Keren-Raifman T, Ivanina T, Bismuth Y, Dascal N., Biochem Biophys Res Commun. August 11, 2000; 274 (3): 852-8.

Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels., Fajloun Z, Carlier E, Lecomte C, Geib S, Di Luccio E, Bichet D, Mabrouk K, Rochat H, De Waard M, Sabatier JM., Eur J Biochem. August 1, 2000; 267 (16): 5149-55.

Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34., Lecomte C, Ben Khalifa R, Martin-Eauclaire MF, Kharrat R, El Ayeb M, Darbon H, Rochat H, Crest M, Sabatier JM., J Pept Res. March 1, 2000; 55 (3): 246-54.

A functional spliced-variant of beta 2 subunit of Kv1 channels in C6 glioma cells and reactive astrocytes from rat lesioned cerebellum., Akhtar S, McIntosh P, Bryan-Sisneros A, Barratt L, Robertson B, Dolly JO., Biochemistry. December 21, 1999; 38 (51): 16984-92.

Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity., Alessandri-Haber N, Lecoq A, Gasparini S, Grangier-Macmath G, Jacquet G, Harvey AL, de Medeiros C, Rowan EG, Gola M, Ménez A, Crest M., J Biol Chem. December 10, 1999; 274 (50): 35653-61.

NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1., Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B., J Biol Chem. December 10, 1999; 274 (50): 35521-5.

Modal behavior of the Kv1.1 channel conferred by the Kvbeta1.1 subunit and its regulation by dephosphorylation of Kv1.1., Singer-Lahat D, Dascal N, Lotan I., Pflugers Arch. December 1, 1999; 439 (1-2): 18-26.

Inhibition of neuronal KV potassium currents by the antidepressant drug, fluoxetine., Yeung SY, Millar JA, Mathie A., Br J Pharmacol. December 1, 1999; 128 (7): 1609-15.

Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits., Mourre C, Chernova MN, Martin-Eauclaire MF, Bessone R, Jacquet G, Gola M, Alper SL, Crest M., J Pharmacol Exp Ther. December 1, 1999; 291 (3): 943-52.

Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin., Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS., Biochemistry. November 2, 1999; 38 (44): 14549-58.

Voltage sensitivity and gating charge in Shaker and Shab family potassium channels., Islas LD, Sigworth FJ., J Gen Physiol. November 1, 1999; 114 (5): 723-42.                      

Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function., D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M., FASEB J. August 1, 1999; 13 (11): 1335-45.

Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1.1 and 1.2 alpha subunits., Wang FC, Bell N, Reid P, Smith LA, McIntosh P, Robertson B, Dolly JO., Eur J Biochem. July 1, 1999; 263 (1): 222-9.

Protein kinase C inhibits Kv1.1 potassium channel function., Boland LM, Jackson KA., Am J Physiol. July 1, 1999; 277 (1): C100-10.

Functional characterization of a novel mutation in KCNA1 in episodic ataxia type 1 associated with epilepsy., Spauschus A, Eunson L, Hanna MG, Kullmann DM., Ann N Y Acad Sci. April 30, 1999; 868 442-6.

Ile-177 and Ser-180 in the S1 segment are critically important in Kv1.1 channel function., Mathur R, Zhou J, Babila T, Koren G., J Biol Chem. April 23, 1999; 274 (17): 11487-93.

Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits., Jing J, Chikvashvili D, Singer-Lahat D, Thornhill WB, Reuveny E, Lotan I., EMBO J. March 1, 1999; 18 (5): 1245-56.

Transplanting the N-terminus from Kv1.4 to Kv1.1 generates an inwardly rectifying K+ channel., Chanda B, Tiwari JK, Varshney A, Mathew MK., Neuroreport. February 5, 1999; 10 (2): 237-41.

Open channel block and open channel destabilization: contrasting effects of phenol, TEA+ and local anaesthetics on Kv1.1 K+ channels., Elliott AA, Harrold JA, Newman JP, Elliott JR., Toxicol Lett. November 23, 1998; 100-101 277-85.

Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas., Newcomb R, Szoke B, Palma A, Wang G, Chen X, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos J, Miljanich G., Biochemistry. November 3, 1998; 37 (44): 15353-62.

A snake toxin inhibitor of inward rectifier potassium channel ROMK1., Imredy JP, Chen C, MacKinnon R., Biochemistry. October 20, 1998; 37 (42): 14867-74.

Characterization of three episodic ataxia mutations in the human Kv1.1 potassium channel., Zerr P, Adelman JP, Maylie J., FEBS Lett. July 24, 1998; 431 (3): 461-4.

Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels., Martínez F, Muñoz-Garay C, Gurrola G, Darszon A, Possani LD, Becerril B., FEBS Lett. June 16, 1998; 429 (3): 381-4.

Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes., Hopkins WF., J Pharmacol Exp Ther. June 1, 1998; 285 (3): 1051-60.

Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency., Zerr P, Adelman JP, Maylie J., J Neurosci. April 15, 1998; 18 (8): 2842-8.

Activation of a metabotropic glutamate receptor and protein kinase C reduce the extent of inactivation of the K+ channel Kv1.1/Kvbeta1.1 via dephosphorylation of Kv1.1., Levy M, Jing J, Chikvashvili D, Thornhill WB, Lotan I., J Biol Chem. March 13, 1998; 273 (11): 6495-502.

Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes., Chen H, Kubo Y, Hoshi T, Heinemann SH., FEBS Lett. February 6, 1998; 422 (3): 307-10.

kappa-Conotoxin PVIIA is a peptide inhibiting the shaker K+ channel., Shon KJ, Stocker M, Terlau H, Stühmer W, Jacobsen R, Walker C, Grilley M, Watkins M, Hillyard DR, Gray WR, Olivera BM., J Biol Chem. January 2, 1998; 273 (1): 33-8.

Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1)., Tytgat J, Maertens C, Daenens P., Br J Pharmacol. December 1, 1997; 122 (7): 1417-24.

A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum., Folco E, Mathur R, Mori Y, Buckett P, Koren G., J Biol Chem. October 17, 1997; 272 (42): 26505-10.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

Inactivation of a voltage-dependent K+ channel by beta subunit. Modulation by a phosphorylation-dependent interaction between the distal C terminus of alpha subunit and cytoskeleton., Jing J, Peretz T, Singer-Lahat D, Chikvashvili D, Thornhill WB, Lotan I., J Biol Chem. May 30, 1997; 272 (22): 14021-4.

Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels., Kharrat R, Mansuelle P, Sampieri F, Crest M, Oughideni R, Van Rietschoten J, Martin-Eauclaire MF, Rochat H, El Ayeb M., FEBS Lett. April 14, 1997; 406 (3): 284-90.

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes., Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE., Br J Pharmacol. March 1, 1997; 120 (5): 968-74.

Effect of lanthanum on voltage-dependent gating of a cloned mammalian neuronal potassium channel., Tytgat J, Daenens P., Dev Biol. February 28, 1997; 749 (2): 232-7.

A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity., Cotton J, Crest M, Bouet F, Alessandri N, Gola M, Forest E, Karlsson E, Castañeda O, Harvey AL, Vita C, Ménez A., Eur J Biochem. February 15, 1997; 244 (1): 192-202.

Phosphorylation of a K+ channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton., Levin G, Chikvashvili D, Singer-Lahat D, Peretz T, Thornhill WB, Lotan I., J Biol Chem. November 15, 1996; 271 (46): 29321-8.

Specific blockade of slowly activating I(sK) channels by chromanols -- impact on the role of I(sK) channels in epithelia., Suessbrich H, Bleich M, Ecke D, Rizzo M, Waldegger S, Lang F, Szabo I, Lang HJ, Kunzelmann K, Greger R, Busch AE., FEBS Lett. November 4, 1996; 396 (2-3): 271-5.

Do voltage-gated Kv1.1 and inward rectifier Kir2.1 potassium channels form heteromultimers?, Tytgat J, Buyse G, Eggermont J, Droogmans G, Nilius B, Daenens P., FEBS Lett. July 29, 1996; 390 (3): 280-4.

Functional characterization of Kv channel beta-subunits from rat brain., Heinemann SH, Rettig J, Graack HR, Pongs O., J Physiol. June 15, 1996; 493 ( Pt 3) 625-33.

Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney., Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV., J Clin Invest. June 1, 1996; 97 (11): 2525-33.

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