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Summary Expression Phenotypes Gene Literature (190) GO Terms (26) Nucleotides (140) Proteins (57) Interactants (149) Wiki
XB--5921461

Papers associated with kcnq1



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Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel., Zaydman MA, Kasimova MA, McFarland K, Beller Z, Hou P, Kinser HE, Liang H, Zhang G, Shi J, Tarek M, Cui J., Elife. March 12, 2014; 3 e03606.                        

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability., Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT., Sci Signal. March 4, 2014; 7 (315): ra22.

Upregulation of KCNQ1/KCNE1 K+ channels by Klotho., Almilaji A, Pakladok T, Muñoz C, Elvira B, Sopjani M, Lang F., Channels (Austin). January 1, 2014; 8 (3): 222-9.

Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)., Li Y, Gao J, Lu Z, McFarland K, Shi J, Bock K, Cohen IS, Cui J., Proc Natl Acad Sci U S A. November 19, 2013; 110 (47): 18922-7.

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene., Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT., Development. November 1, 2013; 140 (21): 4362-74.              

Coxsackievirus B3 modulates cardiac ion channels., Steinke K, Sachse F, Ettischer N, Strutz-Seebohm N, Henrion U, Rohrbeck M, Klosowski R, Wolters D, Brunner S, Franz WM, Pott L, Munoz C, Kandolf R, Schulze-Bahr E, Lang F, Klingel K, Seebohm G., FASEB J. October 1, 2013; 27 (10): 4108-21.

Differential effects of ginsenoside metabolites on slowly activating delayed rectifier K(+) and KCNQ1 K(+) channel currents., Choi SH, Lee BH, Kim HJ, Jung SW, Hwang SH, Nah SY., J Ginseng Res. July 1, 2013; 37 (3): 324-31.          

Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome., Hoosien M, Ahearn ME, Myerburg RJ, Pham TV, Miller TE, Smets MJ, Baumbach-Reardon L, Young ML, Farooq A, Bishopric NH., Heart Rhythm. May 1, 2013; 10 (5): 728-37.

Purinergic signalling - a possible mechanism for KCNQ1 channel response to cell volume challenges., Hammami S, Willumsen NJ, Meinild AK, Klaerke DA, Novak I., Acta Physiol (Oxf). March 1, 2013; 207 (3): 503-15.

Rab GTPases are required for early orientation of the left-right axis in Xenopus., Vandenberg LN, Morrie RD, Seebohm G, Lemire JM, Levin M., Mech Dev. January 1, 2013; 130 (4-5): 254-71.                      

Chemical derivatization and purification of peptide-toxins for probing ion channel complexes., Hua Z, Kobertz WR., Methods Mol Biol. January 1, 2013; 995 19-30.

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation., Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F., FASEB J. October 1, 2012; 26 (10): 4243-53.

Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries., Chadha PS, Zunke F, Davis AJ, Jepps TA, Linders JT, Schwake M, Towart R, Greenwood IA., Br J Pharmacol. June 1, 2012; 166 (4): 1377-87.

Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels., Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP., Proc Natl Acad Sci U S A. May 1, 2012; 109 (18): 7103-8.

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels., Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen SP, Abriel H, Jespersen T., Heart Rhythm. March 1, 2012; 9 (3): 440-8.

Regulation of KCNQ1/KCNE1 by β-catenin., Wilmes J, Haddad-Tóvolli R, Alesutan I, Munoz C, Sopjani M, Pelzl L, Bogatikov E, Fedele G, Faggio C, Seebohm G, Föller M, Lang F., Mol Membr Biol. January 1, 2012; 29 (3-4): 87-94.

Overlapping cardiac phenotype associated with a familial mutation in the voltage sensor of the KCNQ1 channel., Henrion U, Zumhagen S, Steinke K, Strutz-Seebohm N, Stallmeyer B, Lang F, Schulze-Bahr E, Seebohm G., Cell Physiol Biochem. January 1, 2012; 29 (5-6): 809-18.

Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments., Coey AT, Sahu ID, Gunasekera TS, Troxel KR, Hawn JM, Swartz MS, Wickenheiser MR, Reid RJ, Welch RC, Vanoye CG, Kang C, Sanders CR, Lorigan GA., Biochemistry. December 20, 2011; 50 (50): 10851-9.

Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process., Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M., Biochim Biophys Acta. November 1, 2011; 1812 (11): 1452-9.

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue., Nakajo K, Nishino A, Okamura Y, Kubo Y., J Gen Physiol. November 1, 2011; 138 (5): 521-35.                        

Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state., Larsen AP, Steffensen AB, Grunnet M, Olesen SP., Biophys J. August 17, 2011; 101 (4): 818-27.

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity., Li Y, Zaydman MA, Wu D, Shi J, Guan M, Virgin-Downey B, Cui J., Proc Natl Acad Sci U S A. May 31, 2011; 108 (22): 9095-100.

Biophysical properties of mutant KCNQ1 S277L channels linked to hereditary long QT syndrome with phenotypic variability., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Biochim Biophys Acta. April 1, 2011; 1812 (4): 488-94.

Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients., Jons C, O-Uchi J, Moss AJ, Reumann M, Rice JJ, Goldenberg I, Zareba W, Wilde AA, Shimizu W, Kanters JK, McNitt S, Hofman N, Robinson JL, Lopes CM., Sci Transl Med. March 30, 2011; 3 (76): 76ra28.

Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis., Ma LJ, Ohmert I, Vardanyan V., Biophys J. February 16, 2011; 100 (4): 885-94.

Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase., Alesutan I, Föller M, Sopjani M, Dërmaku-Sopjani M, Zelenak C, Fröhlich H, Velic A, Fraser S, Kemp BE, Seebohm G, Völkl H, Lang F., Mol Membr Biol. February 1, 2011; 28 (2): 79-89.

Gating-related molecular motions in the extracellular domain of the IKs channel: implications for IKs channelopathy., Wang YH, Jiang M, Xu XL, Hsu KL, Zhang M, Tseng GN., J Membr Biol. February 1, 2011; 239 (3): 137-56.

Structural basis of slow activation gating in the cardiac I Ks channel complex., Strutz-Seebohm N, Pusch M, Wolf S, Stoll R, Tapken D, Gerwert K, Attali B, Seebohm G., Cell Physiol Biochem. January 1, 2011; 27 (5): 443-52.

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate., Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS., Proc Natl Acad Sci U S A. December 28, 2010; 107 (52): 22710-5.

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells., Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR., Am J Physiol Renal Physiol. December 1, 2010; 299 (6): F1308-19.

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex., Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY., Proc Natl Acad Sci U S A. November 2, 2010; 107 (44): 18862-7.

Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit., Choi SH, Shin TJ, Lee BH, Chu DH, Choe H, Pyo MK, Hwang SH, Kim BR, Lee SM, Lee JH, Lee JH, Kim DH, Kim HC, Rhim HW, Nah SY., Eur J Pharmacol. July 10, 2010; 637 (1-3): 138-47.

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation., Wu D, Delaloye K, Zaydman MA, Nekouzadeh A, Rudy Y, Cui J., J Gen Physiol. June 1, 2010; 135 (6): 595-606.                  

A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor., Choi E, Abbott GW., FASEB J. May 1, 2010; 24 (5): 1518-24.

Functional delivery of a membrane protein into oocyte membranes using bicelles., Kang C, Vanoye CG, Welch RC, Van Horn WD, Sanders CR., Biochemistry. February 2, 2010; 49 (4): 653-5.

KCNQ1/KCNE1 assembly, co-translation not required., Vanoye CG, Welch RC, Tian C, Sanders CR, George AL., Channels (Austin). January 1, 2010; 4 (2): 108-14.

PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions., Matavel A, Medei E, Lopes CM., Channels (Austin). January 1, 2010; 4 (1): 3-11.

Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity., Regev N, Degani-Katzav N, Korngreen A, Etzioni A, Siloni S, Alaimo A, Chikvashvili D, Villarroel A, Attali B, Lotan I., PLoS One. August 13, 2009; 4 (8): e6586.              

The G314S KCNQ1 mutation exerts a dominant-negative effect on expression of KCNQ1 channels in oocytes., Li W, Du R, Wang QF, Tian L, Yang JG, Song ZF., Biochem Biophys Res Commun. May 29, 2009; 383 (2): 206-9.

Cell volume and membrane stretch independently control K+ channel activity., Hammami S, Willumsen NJ, Olsen HL, Morera FJ, Latorre R, Klaerke DA., J Physiol. May 15, 2009; 587 (Pt 10): 2225-31.

PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors., Matavel A, Lopes CM., J Mol Cell Cardiol. May 1, 2009; 46 (5): 704-12.

Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes., Mruk K, Kobertz WR., PLoS One. January 1, 2009; 4 (1): e4236.          

Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels., Henrion U, Strutz-Seebohm N, Duszenko M, Lang F, Seebohm G., Cell Physiol Biochem. January 1, 2009; 24 (1-2): 11-6.

Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels., Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F., Circ Res. December 5, 2008; 103 (12): 1451-7.

Cardiac ion channel gene mutations in sudden infant death syndrome., Otagiri T, Kijima K, Osawa M, Ishii K, Makita N, Matoba R, Umetsu K, Hayasaka K., Pediatr Res. November 1, 2008; 64 (5): 482-7.

Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells., Morokuma J, Blackiston D, Adams DS, Seebohm G, Trimmer B, Levin M., Proc Natl Acad Sci U S A. October 28, 2008; 105 (43): 16608-13.                                  

Voltage-dependent C-type inactivation in a constitutively open K+ channel., Panaghie G, Purtell K, Tai KK, Abbott GW., Biophys J. September 15, 2008; 95 (6): 2759-78.

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents., Yeung S, Schwake M, Pucovský V, Greenwood Ia., Br J Pharmacol. September 1, 2008; 155 (1): 62-72.

Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels., Restier L, Cheng L, Sanguinetti MC., J Physiol. September 1, 2008; 586 (17): 4179-91.

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