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Summary Expression Phenotypes Gene Literature (94) GO Terms (4) Nucleotides (150) Proteins (32) Interactants (205) Wiki
XB--5994597

Papers associated with chrna4



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Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization., Papke RL., J Mol Neurosci. January 1, 2010; 40 (1-2): 77-86.


The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits., Williamson SM, Robertson AP, Brown L, Williams T, Woods DJ, Martin RJ, Sattelle DB, Wolstenholme AJ., PLoS Pathog. July 1, 2009; 5 (7): e1000517.            


Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene., Hoda JC, Wanischeck M, Bertrand D, Steinlein OK., FEBS Lett. May 19, 2009; 583 (10): 1599-604.


Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity., Wang J, Papke RL, Horenstein NA., Bioorg Med Chem Lett. January 15, 2009; 19 (2): 474-6.


Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles of pathogenic nicotinic acetylcholine receptor beta-subunit mutations outside the ion channel pore., Hoda JC, Gu W, Friedli M, Phillips HA, Bertrand S, Antonarakis SE, Goudie D, Roberts R, Scheffer IE, Marini C, Patel J, Berkovic SF, Mulley JC, Steinlein OK, Bertrand D., Mol Pharmacol. August 1, 2008; 74 (2): 379-91.


SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production., Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM., J Cell Biol. June 30, 2008; 181 (7): 1107-16.                


Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop., Jansen M, Bali M, Akabas MH., J Gen Physiol. February 1, 2008; 131 (2): 137-46.        


Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy., Wuttke TV, Penzien J, Fauler M, Seebohm G, Lehmann-Horn F, Lerche H, Jurkat-Rott K., J Physiol. January 15, 2008; 586 (2): 545-55.


Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity., Wotring VE, Weiss DS., J Gen Physiol. January 1, 2008; 131 (1): 87-97.              


Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation., Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley T, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, Petrou S, Murphy M, Waddington J, Horne MK, Berkovic SF, Drago J., J Neurosci. September 19, 2007; 27 (38): 10128-42.


Association of attentional network function with exon 5 variations of the CHRNA4 gene., Winterer G, Musso F, Konrad A, Vucurevic G, Stoeter P, Sander T, Gallinat J., Hum Mol Genet. September 15, 2007; 16 (18): 2165-74.


Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes., Grønlien JH, Håkerud M, Ween H, Thorin-Hagene K, Briggs CA, Gopalakrishnan M, Malysz J., Mol Pharmacol. September 1, 2007; 72 (3): 715-24.


AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity., Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ., EMBO J. August 22, 2007; 26 (16): 3858-67.          


Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons., Lopez-Hernandez G, Placzek AN, Thinschmidt JS, Lestage P, Trocme-Thibierge C, Morain P, Papke RL., Neuropharmacology. July 1, 2007; 53 (1): 134-44.


Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics., Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL., BMC Struct Biol. April 20, 2007; 7 28.            


Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation., Mozayan M, Chen MF, Si M, Chen PY, Premkumar LS, Lee TJ., J Cereb Blood Flow Metab. December 1, 2006; 26 (12): 1562-76.


Subthreshold changes of voltage-dependent activation of the K(V)7.2 channel in neonatal epilepsy., Hunter J, Maljevic S, Shankar A, Siegel A, Weissman B, Holt P, Olson L, Lerche H, Escayg A., Neurobiol Dis. October 1, 2006; 24 (1): 194-201.


Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation., Long C, Chen MF, Sarwinski SJ, Chen PY, Si M, Hoffer BJ, Evans MS, Lee TJ., Am J Physiol Heart Circ Physiol. July 1, 2006; 291 (1): H202-9.


Estimation of both the potency and efficacy of alpha7 nAChR agonists from single-concentration responses., Papke RL., Life Sci. May 8, 2006; 78 (24): 2812-9.


A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons., Otto JF, Yang Y, Frankel WN, White HS, Wilcox KS., J Neurosci. February 15, 2006; 26 (7): 2053-9.


Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR., Ellison M, Haberlandt C, Gomez-Casati ME, Watkins M, Elgoyhen AB, McIntosh JM, Olivera BM., Biochemistry. February 7, 2006; 45 (5): 1511-7.


Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs., van Nierop P, Keramidas A, Bertrand S, van Minnen J, Gouwenberg Y, Bertrand D, Smit AB., J Neurosci. November 16, 2005; 25 (46): 10617-26.


"Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels., Demuro A, Parker I., J Gen Physiol. September 1, 2005; 126 (3): 179-92.                    


The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion., Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA., Bioorg Med Chem Lett. September 1, 2005; 15 (17): 3874-80.


Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors., Groot-Kormelink PJ, Broadbent SD, Boorman JP, Sivilotti LG., J Gen Physiol. June 1, 2004; 123 (6): 697-708.              


Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy., Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK., Neuropharmacology. June 1, 2004; 46 (7): 1023-38.


KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum., Singh NA, Westenskow P, Charlier C, Pappas C, Leslie J, Dillon J, Anderson VE, Sanguinetti MC, Leppert MF, BFNC Physician Consortium., Brain. December 1, 2003; 126 (Pt 12): 2726-37.


Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current., Macdonald RL, Bianchi MT, Bianch MT, Feng H., Exp Neurol. November 1, 2003; 184 Suppl 1 S58-67.


Specific activation of the acetylcholine receptor subunit genes by MyoD family proteins., Charbonnier F, Della Gaspara B, Armand AS, Lécolle S, Launay T, Gallien CL, Chanoine C., J Biol Chem. August 29, 2003; 278 (35): 33169-74.          


A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes., Coppola G, Castaldo P, Miraglia del Giudice E, Bellini G, Galasso F, Soldovieri MV, Anzalone L, Sferro C, Annunziato L, Pascotto A, Taglialatela M., Neurology. July 8, 2003; 61 (1): 131-4.


A new Chrna4 mutation with low penetrance in nocturnal frontal lobe epilepsy., Leniger T, Kananura C, Hufnagel A, Bertrand S, Bertrand D, Steinlein OK., Epilepsia. July 1, 2003; 44 (7): 981-5.


Activation and desensitization of the recombinant P2X1 receptor at nanomolar ATP concentrations., Rettinger J, Schmalzing G., J Gen Physiol. May 1, 2003; 121 (5): 451-61.          


Neonatal convulsions and epileptic encephalopathy in an Italian family with a missense mutation in the fifth transmembrane region of KCNQ2., Dedek K, Fusco L, Teloy N, Steinlein OK., Epilepsy Res. April 1, 2003; 54 (1): 21-7.


Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis., Papke RL, Porter Papke JK., Br J Pharmacol. September 1, 2002; 137 (1): 49-61.


Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels., Castaldo P, del Giudice EM, Coppola G, Pascotto A, Annunziato L, Taglialatela M., J Neurosci. January 15, 2002; 22 (2): RC199.


Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel., Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK., Proc Natl Acad Sci U S A. October 9, 2001; 98 (21): 12272-7.


Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy., Schwake M, Pusch M, Kharkovets T, Jentsch TJ., J Biol Chem. May 5, 2000; 275 (18): 13343-8.


Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity., Luo S, Nguyen TA, Cartier GE, Olivera BM, Yoshikami D, McIntosh JM., Biochemistry. November 2, 1999; 38 (44): 14542-8.


A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions., Lerche H, Biervert C, Alekov AK, Schleithoff L, Lindner M, Klinger W, Bretschneider F, Mitrovic N, Jurkat-Rott K, Bode H, Lehmann-Horn F, Steinlein OK., Ann Neurol. September 1, 1999; 46 (3): 305-12.


Neuronal nAChR stereoselectivity to non-natural epibatidine derivatives., Bertrand S, Patt JT, Spang JE, Westera G, Schubiger PA, Bertrand D., FEBS Lett. May 7, 1999; 450 (3): 273-9.


The long cytoplasmic loop of the alpha 3 subunit targets specific nAChR subtypes to synapses on neurons in vivo., Williams BM, Temburni MK, Bertrand S, Bertrand D, Jacob MH., Ann N Y Acad Sci. April 30, 1999; 868 640-4.


Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy., Schroeder BC, Kubisch C, Stein V, Jentsch TJ., Nature. December 17, 1998; 396 (6712): 687-90.


Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy., Yang WP, Levesque PC, Little WA, Conder ML, Ramakrishnan P, Neubauer MG, Blanar MA., J Biol Chem. July 31, 1998; 273 (31): 19419-23.


A potassium channel mutation in neonatal human epilepsy., Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK., Science. January 16, 1998; 279 (5349): 403-6.

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