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Summary Expression Phenotypes Gene Literature (117) GO Terms (4) Nucleotides (52) Proteins (37) Interactants (118) Wiki
XB--991583

Papers associated with kcna2



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Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination., Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR., Pflugers Arch. June 1, 2009; 458 (2): 259-72.

The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating., Mazzolini M, Anselmi C, Torre V., J Gen Physiol. April 1, 2009; 133 (4): 375-86.            

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels., Lee SY, Banerjee A, MacKinnon R., PLoS Biol. March 3, 2009; 7 (3): e47.              

Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation., Findeisen F, Minor DL., J Gen Physiol. March 1, 2009; 133 (3): 327-43.              

Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels., Barghaan J, Bähring R., J Gen Physiol. February 1, 2009; 133 (2): 205-24.                    

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels., Lange W, Geissendörfer J, Schenzer A, Grötzinger J, Seebohm G, Friedrich T, Schwake M., Mol Pharmacol. February 1, 2009; 75 (2): 272-80.

The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel., Peters CJ, Vaid M, Horne AJ, Fedida D, Accili EA., Channels (Austin). January 1, 2009; 3 (5): 314-22.

A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes., Abbas N, Belghazi M, Abdel-Mottaleb Y, Tytgat J, Bougis PE, Martin-Eauclaire MF., Biochem Biophys Res Commun. November 21, 2008; 376 (3): 525-30.

Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus., Srairi-Abid N, Shahbazzadeh D, Chatti I, Mlayah-Bellalouna S, Mejdoub H, Borchani L, Benkhalifa R, Akbari A, El Ayeb M., FEBS J. September 1, 2008; 275 (18): 4641-50.

KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains., Xu X, Jiang M, Hsu KL, Zhang M, Tseng GN., J Gen Physiol. June 1, 2008; 131 (6): 589-603.                    

Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure., Lewis A, Jogini V, Blachowicz L, Lainé M, Roux B., J Gen Physiol. June 1, 2008; 131 (6): 549-61.                

An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels., Ma Z, Wong KY, Horrigan FT., J Gen Physiol. May 1, 2008; 131 (5): 483-502.                      

Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block., Carvacho I, Gonzalez W, Torres YP, Brauchi S, Alvarez O, Gonzalez-Nilo FD, Latorre R., J Gen Physiol. February 1, 2008; 131 (2): 147-61.                        

Mg2+ enhances voltage sensor/gate coupling in BK channels., Horrigan FT, Ma Z., J Gen Physiol. January 1, 2008; 131 (1): 13-32.                

Tarantula toxins interact with voltage sensors within lipid membranes., Milescu M, Vobecky J, Roh SH, Kim SH, Jung HJ, Kim JI, Swartz KJ., J Gen Physiol. November 1, 2007; 130 (5): 497-511.                    

Molecular driving forces determining potassium channel slow inactivation., Cordero-Morales JF, Jogini V, Lewis A, Vásquez V, Cortes DM, Roux B, Perozo E., Nat Struct Mol Biol. November 1, 2007; 14 (11): 1062-9.

An essential role for cortactin in the modulation of the potassium channel Kv1.2., Williams MR, Markey JC, Doczi MA, Morielli AD., Proc Natl Acad Sci U S A. October 30, 2007; 104 (44): 17412-7.

The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels., Raybaud A, Baspinar EE, Dionne F, Dodier Y, Sauvé R, Parent L., J Biol Chem. September 21, 2007; 282 (38): 27944-52.

KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel., Nakajo K, Kubo Y., J Gen Physiol. September 1, 2007; 130 (3): 269-81.            

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes., Panaghie G, Abbott GW., J Gen Physiol. February 1, 2007; 129 (2): 121-33.                      

Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels., Nie H, Yu WJ, Li XY, Yuan CH, Pang YP, Li CY, Han YF, Li ZW., Neurosci Lett. January 29, 2007; 412 (2): 108-13.

The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae., Abdel-Mottaleb Y, Clynen E, Jalali A, Bosmans F, Vatanpour H, Schoofs L, Tytgat J., FEBS Lett. November 13, 2006; 580 (26): 6254-8.

Membrane stretch slows the concerted step prior to opening in a Kv channel., Laitko U, Juranka PF, Morris CE., J Gen Physiol. June 1, 2006; 127 (6): 687-701.                  

Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate., Contreras JE, Holmgren M., J Gen Physiol. May 1, 2006; 127 (5): 481-94.                        

Analysis of voltage-gated potassium channel beta1 subunits in the porcine neonatal ductus arteriosus., Hayama E, Imamura S, Wu C, Nakazawa M, Matsuoka R, Nakanishi T., Pediatr Res. February 1, 2006; 59 (2): 167-74.

A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction., Persson AS, Klement G, Almgren M, Sahlholm K, Nilsson J, Petersson S, Arhem P, Schalling M, Lavebratt C., BMC Neurosci. November 23, 2005; 6 65.          

Status of the intracellular gate in the activated-not-open state of shaker K+ channels., del Camino D, Kanevsky M, Yellen G., J Gen Physiol. November 1, 2005; 126 (5): 419-28.          

Effects of Kv1.2 intracellular regions on activation of Kv2.1 channels., Scholle A, Zimmer T, Koopmann R, Engeland B, Pongs O, Benndorf K., Biophys J. August 1, 2004; 87 (2): 873-82.

Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels., M'Barek S, Mosbah A, Sandoz G, Fajloun Z, Olamendi-Portugal T, Rochat H, Sampieri F, Guijarro JI, Mansuelle P, Delepierre M, De Waard M, Sabatier JM., Eur J Biochem. September 1, 2003; 270 (17): 3583-92.

The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity., Conforti L, Takimoto K, Petrovic M, Pongs O, Millhorn D., Biochem Biophys Res Commun. June 27, 2003; 306 (2): 450-6.

Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Nilsson J, Madeja M, Arhem P., Mol Pharmacol. June 1, 2003; 63 (6): 1417-29.

Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin., Hattan D, Nesti E, Cachero TG, Morielli AD., J Biol Chem. October 11, 2002; 277 (41): 38596-606.

Modulation of voltage sensitivity by N-terminal cytoplasmic residues in human Kv1.2 channels., Varshney A, S K, Mathew MK., Eur Biophys J. September 1, 2002; 31 (5): 365-72.

Characteristics of brain Kv1 channels tailored to mimic native counterparts by tandem linkage of alpha subunits: implications for K+ channelopathies., Akhtar S, Shamotienko O, Papakosta M, Ali F, Dolly JO., J Biol Chem. May 10, 2002; 277 (19): 16376-82.

Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2)., McCormack K, Connor JX, Zhou L, Ho LL, Ganetzky B, Chiu SY, Messing A., J Biol Chem. April 12, 2002; 277 (15): 13219-28.

Expression and function of native potassium channel [K(V)alpha1] subunits in terminal arterioles of rabbit., Cheong A, Dedman AM, Beech DJ., J Physiol. August 1, 2001; 534 (Pt 3): 691-700.

Cloning and expression of three K+ channel cDNAs from Xenopus muscle., Fry M, Paterno G, Moody-Corbett F., Brain Res Mol Brain Res. June 20, 2001; 90 (2): 135-48.          

Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes., Hinck D, Wulff H, Koppenhöfer E., Gen Physiol Biophys. March 1, 2001; 20 (1): 83-95.

Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels., Fajloun Z, Carlier E, Lecomte C, Geib S, Di Luccio E, Bichet D, Mabrouk K, Rochat H, De Waard M, Sabatier JM., Eur J Biochem. August 1, 2000; 267 (16): 5149-55.

Inhibition of the K+ channel kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery from N-type inactivation., Claydon TW, Boyett MR, Sivaprasadarao A, Ishii K, Owen JM, O'Beirne HA, Leach R, Komukai K, Orchard CH., J Physiol. July 15, 2000; 526 Pt 2 253-64.

O2-sensitive K+ channels: role of the Kv1.2 -subunit in mediating the hypoxic response., Conforti L, Bodi I, Nisbet JW, Millhorn DE., J Physiol. May 1, 2000; 524 Pt 3 783-93.

Regulation of Shaker-type potassium channels by hypoxia. Oxygen-sensitive K+ channels in PC12 cells., Conforti L, Millhorn DE., Adv Exp Med Biol. January 1, 2000; 475 265-74.

Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity., Alessandri-Haber N, Lecoq A, Gasparini S, Grangier-Macmath G, Jacquet G, Harvey AL, de Medeiros C, Rowan EG, Gola M, Ménez A, Crest M., J Biol Chem. December 10, 1999; 274 (50): 35653-61.

Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits., Mourre C, Chernova MN, Martin-Eauclaire MF, Bessone R, Jacquet G, Gola M, Alper SL, Crest M., J Pharmacol Exp Ther. December 1, 1999; 291 (3): 943-52.

Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor., Steidl JV, Yool AJ., Mol Pharmacol. May 1, 1999; 55 (5): 812-20.

Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity., Tsai W, Morielli AD, Cachero TG, Peralta EG., EMBO J. January 4, 1999; 18 (1): 109-18.

Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes., Hopkins WF., J Pharmacol Exp Ther. June 1, 1998; 285 (3): 1051-60.

Separable Kvbeta subunit domains alter expression and gating of potassium channels., Accili EA, Kiehn J, Yang Q, Wang Z, Brown AM, Wible BA., J Biol Chem. October 10, 1997; 272 (41): 25824-31.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels., Kharrat R, Mansuelle P, Sampieri F, Crest M, Oughideni R, Van Rietschoten J, Martin-Eauclaire MF, Rochat H, El Ayeb M., FEBS Lett. April 14, 1997; 406 (3): 284-90.

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