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Summary Expression Phenotypes Gene Literature (141) GO Terms (0) Nucleotides (27) Proteins (24) Interactants (248) Wiki
XB--996922

Papers associated with abcc8



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Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy., Proks P, Girard C, Baevre H, Njølstad PR, Ashcroft FM., Diabetes. June 1, 2006; 55 (6): 1731-7.

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects., Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersley AT, Barbetti F, Ashcroft FM., Diabetes. June 1, 2006; 55 (6): 1705-12.

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes., Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S., Hum Mol Genet. June 1, 2006; 15 (11): 1793-800.

Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels., Tammaro P, Proks P, Ashcroft FM., J Physiol. February 15, 2006; 571 (Pt 1): 3-14.

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP., Proks P, Girard C, Ashcroft FM., Hum Mol Genet. September 15, 2005; 14 (18): 2717-26.

Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channel., Li L, Geng X, Yonkunas M, Su A, Densmore E, Tang P, Drain P., J Gen Physiol. September 1, 2005; 126 (3): 285-99.                  

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions., Tammaro P, Girard C, Molnes J, Njølstad PR, Ashcroft FM., EMBO J. July 6, 2005; 24 (13): 2318-30.

Relapsing diabetes can result from moderately activating mutations in KCNJ11., Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT., Hum Mol Genet. April 1, 2005; 14 (7): 925-34.

Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators., Hambrock A, Kayar T, Stumpp D, Osswald H., Diabetes. December 1, 2004; 53 Suppl 3 S128-34.

Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains., Campbell JD, Proks P, Lippiat JD, Sansom MS, Ashcroft FM., Diabetes. December 1, 2004; 53 Suppl 3 S123-7.

Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes., Lim JG, Lee HY, Yun JE, Kim SP, Park JW, Suh SI, Jang BC, Cho CH, Bae JH, Kim SS, Han J, Park MJ, Song DK., Biochem Pharmacol. September 1, 2004; 68 (5): 901-10.

Zinc is both an intracellular and extracellular regulator of KATP channel function., Prost AL, Bloc A, Hussy N, Derand R, Vivaudou M., J Physiol. August 15, 2004; 559 (Pt 1): 157-67.

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2., Dabrowski M, Tarasov A, Ashcroft FM., J Physiol. June 1, 2004; 557 (Pt 2): 347-54.

Concerted gating mechanism underlying KATP channel inhibition by ATP., Drain P, Geng X, Li L., Biophys J. April 1, 2004; 86 (4): 2101-12.

Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1., Park EJ, Bae JH, Kim SY, Lim JG, Baek WK, Kwon TK, Suh SI, Park JW, Lee IK, Ashcroft FM, Song DK., Biochem Pharmacol. March 15, 2004; 67 (6): 1089-96.

Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A., Kovalev H, Quayle JM, Kamishima T, Lodwick D., Br J Pharmacol. March 1, 2004; 141 (5): 867-73.

3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists., Peat AJ, Townsend C, Craig McKay M, Garrido D, Terry CM, Wilson JL, Thomson SA., Bioorg Med Chem Lett. February 9, 2004; 14 (3): 813-6.

Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues., Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P., Diabetologia. October 1, 2003; 46 (10): 1375-82.

The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish., Trinh LA, Meyer D, Stainier DY., Development. October 1, 2003; 130 (20): 4989-98.

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators., Prost A, Dérand R, Gros L, Becq F, Vivaudou M., Biochem Pharmacol. August 1, 2003; 66 (3): 425-30.

N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits., Chan KW, Zhang H, Logothetis DE., EMBO J. August 1, 2003; 22 (15): 3833-43.

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes., Dabrowski M, Trapp S, Ashcroft FM., J Physiol. July 15, 2003; 550 (Pt 2): 357-63.

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides., Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM., J Physiol. February 15, 2003; 547 (Pt 1): 159-68.

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population., Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM., Diabetologia. February 1, 2003; 46 (2): 241-9.

Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions., Gribble FM, Reimann F., J Diabetes Complications. January 1, 2003; 17 (2 Suppl): 11-5.

K(ATP) channel activity is required for hatching in Xenopus embryos., Cheng SM, Chen I, Levin M., Dev Dyn. December 1, 2002; 225 (4): 588-91.        

Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures., Wu J, Xu H, Yang Z, Wang Y, Mao J, Jiang C., J Membr Biol. November 15, 2002; 190 (2): 105-16.

Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382., Proks P, Treinies I, Mest HJ, Trapp S., Eur J Pharmacol. September 27, 2002; 452 (1): 11-9.

Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP., Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C., J Physiol. September 1, 2002; 543 (Pt 2): 495-504.

Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31., Gros L, Trapp S, Dabrowski M, Ashcroft FM, Bataille D, Blache P., Br J Pharmacol. September 1, 2002; 137 (1): 98-106.

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding., Matsuo M, Dabrowski M, Ueda K, Ashcroft FM., EMBO J. August 15, 2002; 21 (16): 4250-8.

The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener., Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P., Diabetes. June 1, 2002; 51 (6): 1896-906.

Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel., Brochiero E, Wallendorf B, Gagnon D, Laprade R, Lapointe JY., Am J Physiol Renal Physiol. February 1, 2002; 282 (2): F289-300.

Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP., Li L, Geng X, Drain P., J Gen Physiol. January 1, 2002; 119 (1): 105-16.                    

Amiloride derivatives are potent blockers of KATP channels., Bollensdorff C, Zimmer T, Benndorf K., Naunyn Schmiedebergs Arch Pharmacol. October 1, 2001; 364 (4): 351-8.

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel., Proks P, Capener CE, Jones P, Ashcroft FM., J Gen Physiol. October 1, 2001; 118 (4): 341-53.                    

Structural basis for the interference between nicorandil and sulfonylurea action., Reimann F, Ashcroft FM, Gribble FM., Diabetes. October 1, 2001; 50 (10): 2253-9.

Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism., Partridge CJ, Beech DJ, Sivaprasadarao A., J Biol Chem. September 21, 2001; 276 (38): 35947-52.

Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression., Konstas AA, Bielfeld-Ackermann A, Korbmacher C., Pflugers Arch. August 1, 2001; 442 (5): 752-61.

The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function., Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO., Biochem Biophys Res Commun. June 22, 2001; 284 (4): 918-22.

Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels., Dabrowski M, Wahl P, Holmes WE, Ashcroft FM., Diabetologia. June 1, 2001; 44 (6): 747-56.

Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current., Bachmann A, Quast U, Russ U., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2001; 363 (6): 590-6.

Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Song DK, Ashcroft FM., Br J Pharmacol. May 1, 2001; 133 (1): 193-9.

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel., Reimann F, Proks P, Ashcroft FM., Br J Pharmacol. April 1, 2001; 132 (7): 1542-8.

ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit., Song DK, Ashcroft FM., J Biol Chem. March 9, 2001; 276 (10): 7143-9.

Interaction of stilbene disulphonates with cloned K(ATP) channels., Proks P, Jones P, Ashcroft FM., Br J Pharmacol. March 1, 2001; 132 (5): 973-82.

Direct interaction of Na-azide with the KATP channel., Trapp S, Ashcroft FM., Br J Pharmacol. November 1, 2000; 131 (6): 1105-12.

The antimalarial agent mefloquine inhibits ATP-sensitive K-channels., Gribble FM, Davis TM, Higham CE, Clark A, Ashcroft FM., Br J Pharmacol. October 1, 2000; 131 (4): 756-60.

Fast1 is required for the development of dorsal axial structures in zebrafish., Sirotkin HI, Gates MA, Kelly PD, Schier AF, Talbot WS., Curr Biol. September 7, 2000; 10 (17): 1051-4.

Identification of molecular regions responsible for the membrane trafficking of Kir6.2., Hough E, Beech DJ, Sivaprasadarao A., Pflugers Arch. July 1, 2000; 440 (3): 481-7.

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