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Summary Expression Phenotypes Gene Literature (192) GO Terms (6) Nucleotides (126) Proteins (56) Interactants (656) Wiki
XB--487965

Papers associated with nkx2-5



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FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis., Schuff M, Siegel D, Bardine N, Oswald F, Donow C, Knöchel W., Dev Biol. January 15, 2010; 337 (2): 259-73.                  

Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/CREB pathway., Keren-Politansky A, Keren A, Bengal E., Dev Biol. November 15, 2009; 335 (2): 374-84.            

Early activation of FGF and nodal pathways mediates cardiac specification independently of Wnt/beta-catenin signaling., Samuel LJ, Latinkić BV., PLoS One. October 28, 2009; 4 (10): e7650.                

Retinoic acid regulates anterior-posterior patterning within the lateral plate mesoderm of Xenopus., Deimling SJ, Drysdale TA., Mech Dev. October 1, 2009; 126 (10): 913-23.                        

NFAT directly regulates Nkx2-5 transcription during cardiac cell differentiation., Chen Y, Chen Y, Cao X., Biol Cell. June 1, 2009; 101 (6): 335-49.

The role of the visceral mesoderm in the development of the gastrointestinal tract., McLin VA, Henning SJ, Jamrich M., Gastroenterology. June 1, 2009; 136 (7): 2074-91.

Mitochondria and calcium signaling in embryonic development., Cao X, Chen Y., Semin Cell Dev Biol. May 1, 2009; 20 (3): 337-45.    

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5., Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y., Dev Biol. March 15, 2009; 327 (2): 376-85.      

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling., Li Y, Rankin SA, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM., Genes Dev. November 1, 2008; 22 (21): 3050-63.                        

Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1., Movassagh M, Philpott A., Cardiovasc Res. August 1, 2008; 79 (3): 436-47.                                

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis., Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I., Nature. July 17, 2008; 454 (7202): 345-9.                        

XHAPLN3 plays a key role in cardiogenesis by maintaining the hyaluronan matrix around heart anlage., Ito Y, Seno S, Nakamura H, Fukui A, Asashima M., Dev Biol. July 1, 2008; 319 (1): 34-45.                          

A crucial role of a high mobility group protein HMGA2 in cardiogenesis., Monzen K, Ito Y, Naito AT, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima M, Nagai R, Komuro I., Nat Cell Biol. May 1, 2008; 10 (5): 567-74.                  

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus., Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R., J Biol Chem. April 25, 2008; 283 (17): 11841-9.                        

The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm., Spagnoli FM, Brivanlou AH., Development. February 1, 2008; 135 (3): 451-61.                                                    

Lessons from the lily pad: Using Xenopus to understand heart disease., Bartlett HL, Weeks DL., Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.

Redundancy and evolution of GATA factor requirements in development of the myocardium., Peterkin T, Gibson A, Patient R., Dev Biol. November 15, 2007; 311 (2): 623-35.          

The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis., Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X., Mol Cell Biol. September 1, 2007; 27 (18): 6420-32.

Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis., Bartlett HL, Sutherland L, Kolker SJ, Welp C, Tajchman U, Desmarais V, Weeks DL., Dev Dyn. September 1, 2007; 236 (9): 2475-84.    

Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination., Hilton EN, Manson FD, Urquhart JE, Johnston JJ, Slavotinek AM, Hedera P, Stattin EL, Nordgren A, Biesecker LG, Black GC., Hum Mol Genet. July 15, 2007; 16 (14): 1773-82.              

Xenopus as a model system for vertebrate heart development., Warkman AS, Krieg PA., Semin Cell Dev Biol. February 1, 2007; 18 (1): 46-53.      

Myoskeletin, a factor related to Myocardin, is expressed in somites and required for hypaxial muscle formation in Xenopus., Zhao H, Rebbert ML, Dawid IB., Int J Dev Biol. January 1, 2007; 51 (4): 315-20.              

Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart., Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH., Cell. December 15, 2006; 127 (6): 1137-50.

Characterization of myeloid cells derived from the anterior ventral mesoderm in the Xenopus laevis embryo., Tashiro S, Sedohara A, Asashima M, Izutsu Y, Maéno M., Dev Growth Differ. October 1, 2006; 48 (8): 499-512.                    

Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart., Allen BG, Allen-Brady K, Weeks DL., Mech Dev. October 1, 2006; 123 (10): 719-29.          

Retinoic acid signaling is essential for formation of the heart tube in Xenopus., Collop AH, Broomfield JA, Chandraratna RA, Yong Z, Deimling SJ, Kolker SJ, Weeks DL, Drysdale TA., Dev Biol. March 1, 2006; 291 (1): 96-109.                  

A gynogenetic screen to isolate naturally occurring recessive mutations in Xenopus tropicalis., Noramly S, Zimmerman L, Cox A, Aloise R, Fisher M, Grainger RM., Mech Dev. March 1, 2005; 122 (3): 273-87.              

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus., Small EM, Warkman AS, Wang DZ, Sutherland LB, Olson EN, Krieg PA., Development. March 1, 2005; 132 (5): 987-97.            

Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes., Terami H, Hidaka K, Katsumata T, Iio A, Morisaki T., Biochem Biophys Res Commun. December 17, 2004; 325 (3): 968-75.

Spatial and temporal expression patterns of Xenopus Nkx-2.3 gene in skin epidermis during metamorphosis., Ma CM., Gene Expr Patterns. November 1, 2004; 5 (1): 129-34.  

Characterization of Xenopus Phox2a and Phox2b defines expression domains within the embryonic nervous system and early heart field., Talikka M, Stefani G, Brivanlou AH, Zimmerman K., Gene Expr Patterns. September 1, 2004; 4 (5): 601-7.      

Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis., Ueyama T, Kasahara H, Ishiwata T, Nie Q, Izumo S., Mol Cell Biol. December 1, 2003; 23 (24): 9222-32.

NKX2.5 mutations in patients with congenital heart disease., McElhinney DB, Geiger E, Blinder J, Benson DW, Goldmuntz E., J Am Coll Cardiol. November 5, 2003; 42 (9): 1650-5.

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart., Stennard FA, Costa MW, Elliott DA, Rankin S, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP., Dev Biol. October 15, 2003; 262 (2): 206-24.  

Amphibian in vitro heart induction: a simple and reliable model for the study of vertebrate cardiac development., Ariizumi T, Kinoshita M, Yokota C, Takano K, Fukuda K, Moriyama N, Malacinski GM, Asashima M., Int J Dev Biol. September 1, 2003; 47 (6): 405-10.      

The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)., Nagel S, Kaufmann M, Drexler HG, MacLeod RA., Cancer Res. September 1, 2003; 63 (17): 5329-34.

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF., Small EM, Krieg PA., Dev Biol. September 1, 2003; 261 (1): 116-31.          

Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5., Funke-Kaiser H, Lemmer J, Langsdorff CV, Thomas A, Kovacevic SD, Strasdat M, Behrouzi T, Zollmann FS, Paul M, Orzechowski HD., FASEB J. August 1, 2003; 17 (11): 1487-9.

Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart., Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S., J Biol Chem. August 1, 2003; 278 (31): 28750-7.

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5., Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D., Nature. July 24, 2003; 424 (6947): 443-7.

PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5., Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA., J Biol Chem. June 20, 2003; 278 (25): 22437-45.

Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome., Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP., J Am Coll Cardiol. June 4, 2003; 41 (11): 2072-6.

Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity., Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ., Genesis. April 1, 2003; 35 (4): 220-6.

Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells., Hidaka K, Lee JK, Lee JK, Kim HS, Ihm CH, Iio A, Ogawa M, Nishikawa S, Kodama I, Morisaki T., FASEB J. April 1, 2003; 17 (6): 740-2.

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes., Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S., J Mol Cell Cardiol. March 1, 2003; 35 (3): 243-56.

Too much Csx/Nkx2-5 is as bad as too little?, Akazawa H, Komuro I., J Mol Cell Cardiol. March 1, 2003; 35 (3): 227-9.

Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD., Watanabe Y, Benson DW, Yano S, Akagi T, Yoshino M, Murray JC., J Med Genet. November 1, 2002; 39 (11): 807-11.

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene., Thattaliyath BD, Firulli BA, Firulli AB., J Mol Cell Cardiol. October 1, 2002; 34 (10): 1335-44.

Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors., Kodama H, Hirotani T, Suzuki Y, Ogawa S, Yamazaki K., Am J Pathol. August 1, 2002; 161 (2): 381-9.

Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity., Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ., J Biol Chem. July 12, 2002; 277 (28): 25775-82.

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