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Summary Expression Phenotypes Gene Literature (106) GO Terms (4) Nucleotides (57) Proteins (33) Interactants (107) Wiki
XB--1010661

Papers associated with kcna1



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Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function., D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M., FASEB J. August 1, 1999; 13 (11): 1335-45.

Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1.1 and 1.2 alpha subunits., Wang FC, Bell N, Reid P, Smith LA, McIntosh P, Robertson B, Dolly JO., Eur J Biochem. July 1, 1999; 263 (1): 222-9.

Protein kinase C inhibits Kv1.1 potassium channel function., Boland LM, Jackson KA., Am J Physiol. July 1, 1999; 277 (1): C100-10.

Functional characterization of a novel mutation in KCNA1 in episodic ataxia type 1 associated with epilepsy., Spauschus A, Eunson L, Hanna MG, Kullmann DM., Ann N Y Acad Sci. April 30, 1999; 868 442-6.

Ile-177 and Ser-180 in the S1 segment are critically important in Kv1.1 channel function., Mathur R, Zhou J, Babila T, Koren G., J Biol Chem. April 23, 1999; 274 (17): 11487-93.

Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits., Jing J, Chikvashvili D, Singer-Lahat D, Thornhill WB, Reuveny E, Lotan I., EMBO J. March 1, 1999; 18 (5): 1245-56.

Transplanting the N-terminus from Kv1.4 to Kv1.1 generates an inwardly rectifying K+ channel., Chanda B, Tiwari JK, Varshney A, Mathew MK., Neuroreport. February 5, 1999; 10 (2): 237-41.

Open channel block and open channel destabilization: contrasting effects of phenol, TEA+ and local anaesthetics on Kv1.1 K+ channels., Elliott AA, Harrold JA, Newman JP, Elliott JR., Toxicol Lett. November 23, 1998; 100-101 277-85.

Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas., Newcomb R, Szoke B, Palma A, Wang G, Chen X, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos J, Miljanich G., Biochemistry. November 3, 1998; 37 (44): 15353-62.

A snake toxin inhibitor of inward rectifier potassium channel ROMK1., Imredy JP, Chen C, MacKinnon R., Biochemistry. October 20, 1998; 37 (42): 14867-74.

Characterization of three episodic ataxia mutations in the human Kv1.1 potassium channel., Zerr P, Adelman JP, Maylie J., FEBS Lett. July 24, 1998; 431 (3): 461-4.

Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels., Martínez F, Muñoz-Garay C, Gurrola G, Darszon A, Possani LD, Becerril B., FEBS Lett. June 16, 1998; 429 (3): 381-4.

Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes., Hopkins WF., J Pharmacol Exp Ther. June 1, 1998; 285 (3): 1051-60.

Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency., Zerr P, Adelman JP, Maylie J., J Neurosci. April 15, 1998; 18 (8): 2842-8.

Activation of a metabotropic glutamate receptor and protein kinase C reduce the extent of inactivation of the K+ channel Kv1.1/Kvbeta1.1 via dephosphorylation of Kv1.1., Levy M, Jing J, Chikvashvili D, Thornhill WB, Lotan I., J Biol Chem. March 13, 1998; 273 (11): 6495-502.

Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes., Chen H, Kubo Y, Hoshi T, Heinemann SH., FEBS Lett. February 6, 1998; 422 (3): 307-10.

kappa-Conotoxin PVIIA is a peptide inhibiting the shaker K+ channel., Shon KJ, Stocker M, Terlau H, Stühmer W, Jacobsen R, Walker C, Grilley M, Watkins M, Hillyard DR, Gray WR, Olivera BM., J Biol Chem. January 2, 1998; 273 (1): 33-8.

Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1)., Tytgat J, Maertens C, Daenens P., Br J Pharmacol. December 1, 1997; 122 (7): 1417-24.

A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum., Folco E, Mathur R, Mori Y, Buckett P, Koren G., J Biol Chem. October 17, 1997; 272 (42): 26505-10.

Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241., Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE., FEBS Lett. September 8, 1997; 414 (2): 435-8.

Inactivation of a voltage-dependent K+ channel by beta subunit. Modulation by a phosphorylation-dependent interaction between the distal C terminus of alpha subunit and cytoskeleton., Jing J, Peretz T, Singer-Lahat D, Chikvashvili D, Thornhill WB, Lotan I., J Biol Chem. May 30, 1997; 272 (22): 14021-4.

Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels., Kharrat R, Mansuelle P, Sampieri F, Crest M, Oughideni R, Van Rietschoten J, Martin-Eauclaire MF, Rochat H, El Ayeb M., FEBS Lett. April 14, 1997; 406 (3): 284-90.

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes., Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE., Br J Pharmacol. March 1, 1997; 120 (5): 968-74.

Effect of lanthanum on voltage-dependent gating of a cloned mammalian neuronal potassium channel., Tytgat J, Daenens P., Dev Biol. February 28, 1997; 749 (2): 232-7.

A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity., Cotton J, Crest M, Bouet F, Alessandri N, Gola M, Forest E, Karlsson E, Castañeda O, Harvey AL, Vita C, Ménez A., Eur J Biochem. February 15, 1997; 244 (1): 192-202.

Phosphorylation of a K+ channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton., Levin G, Chikvashvili D, Singer-Lahat D, Peretz T, Thornhill WB, Lotan I., J Biol Chem. November 15, 1996; 271 (46): 29321-8.

Specific blockade of slowly activating I(sK) channels by chromanols -- impact on the role of I(sK) channels in epithelia., Suessbrich H, Bleich M, Ecke D, Rizzo M, Waldegger S, Lang F, Szabo I, Lang HJ, Kunzelmann K, Greger R, Busch AE., FEBS Lett. November 4, 1996; 396 (2-3): 271-5.

Do voltage-gated Kv1.1 and inward rectifier Kir2.1 potassium channels form heteromultimers?, Tytgat J, Buyse G, Eggermont J, Droogmans G, Nilius B, Daenens P., FEBS Lett. July 29, 1996; 390 (3): 280-4.

Functional characterization of Kv channel beta-subunits from rat brain., Heinemann SH, Rettig J, Graack HR, Pongs O., J Physiol. June 15, 1996; 493 ( Pt 3) 625-33.

Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney., Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV., J Clin Invest. June 1, 1996; 97 (11): 2525-33.

Mechanism of action of the epileptogenic drug pentylenetetrazol on a cloned neuronal potassium channel., Madeja M, Musshoff U, Lorra C, Pongs O, Speckmann EJ., Dev Biol. May 25, 1996; 722 (1-2): 59-70.

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole., Suessbrich H, Waldegger S, Lang F, Busch AE., FEBS Lett. April 29, 1996; 385 (1-2): 77-80.

Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes., Robertson B, Owen D, Stow J, Butler C, Newland C., FEBS Lett. March 25, 1996; 383 (1-2): 26-30.

Effect of isosorbiddinitrate on exogenously expressed slowly activating K+ channels and endogenous K+ channels in Xenopus oocytes., Busch AE, Kopp HG, Waldegger S, Samarzija I, Süssbrich H, Raber G, Kunzelmann K, Ruppersberg JP, Lang F., J Physiol. March 15, 1996; 491 ( Pt 3) 735-41.

Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development., Burger C, Ribera AB., J Neurosci. February 15, 1996; 16 (4): 1412-21.          

The alpha-dendrotoxin footprint on a mammalian potassium channel., Tytgat J, Debont T, Carmeliet E, Daenens P., J Biol Chem. October 20, 1995; 270 (42): 24776-81.

Transmembrane segments critical for potassium channel function., Van de Voorde A, Tytgat J., Biochem Biophys Res Commun. April 26, 1995; 209 (3): 1094-101.

A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits., Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC., J Biol Chem. March 17, 1995; 270 (11): 6272-7.

4-Aminopyridine binding and slow inactivation are mutually exclusive in rat Kv1.1 and Shaker potassium channels., Castle NA, Fadous SR, Logothetis DE, Wang GK., Mol Pharmacol. December 1, 1994; 46 (6): 1175-81.

Reversal of rectification and alteration of selectivity and pharmacology in a mammalian Kv1.1 potassium channel by deletion of domains S1 to S4., Tytgat J, Vereecke J, Carmeliet E., J Physiol. November 15, 1994; 481 ( Pt 1) 7-13.

Aminopyridine block of Kv1.1 potassium channels expressed in mammalian cells and Xenopus oocytes., Castle NA, Fadous S, Logothetis DE, Wang GK., Mol Pharmacol. June 1, 1994; 45 (6): 1242-52.

Pursuing the voltage sensor of a voltage-gated mammalian potassium channel., Tytgat J, Nakazawa K, Gross A, Hess P., J Biol Chem. November 15, 1993; 268 (32): 23777-9.

Primary sensory neurons express a Shaker-like potassium channel gene., Ribera AB, Nguyen DA., J Neurosci. November 1, 1993; 13 (11): 4988-96.                

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?, Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB., Circ Res. June 1, 1993; 72 (6): 1326-36.

The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina., Klumpp DJ, Farber DB, Bowes C, Song EJ, Pinto LH., Cell Mol Neurobiol. December 1, 1991; 11 (6): 611-22.

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