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Summary Expression Phenotypes Gene Literature (112) GO Terms (6) Nucleotides (46) Proteins (32) Interactants (165) Wiki
XB--6084576

Papers associated with kcnj11



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Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2., Dabrowski M, Tarasov A, Ashcroft FM., J Physiol. June 1, 2004; 557 (Pt 2): 347-54.

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes., Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT., N Engl J Med. April 29, 2004; 350 (18): 1838-49.

Concerted gating mechanism underlying KATP channel inhibition by ATP., Drain P, Geng X, Li L., Biophys J. April 1, 2004; 86 (4): 2101-12.

Na(+) current through KATP channels: consequences for Na(+) and K(+) fluxes during early myocardial ischemia., Bollensdorff C, Knopp A, Biskup C, Zimmer T, Benndorf K., Am J Physiol Heart Circ Physiol. January 1, 2004; 286 (1): H283-95.

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes., Dabrowski M, Trapp S, Ashcroft FM., J Physiol. July 15, 2003; 550 (Pt 2): 357-63.

Identification of residues contributing to the ATP binding site of Kir6.2., Trapp S, Haider S, Jones P, Sansom MS, Ashcroft FM., EMBO J. June 16, 2003; 22 (12): 2903-12.

Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels., Konstas AA, Korbmacher C, Tucker SJ., Am J Physiol Cell Physiol. April 1, 2003; 284 (4): C910-7.

A threonine residue (Thr71) at the intracellular end of the M1 helix plays a critical role in the gating of Kir6.2 channels by intracellular ATP and protons., Cui N, Wu J, Xu H, Wang R, Rojas A, Piao H, Mao J, Abdulkadir L, Li L, Jiang C., J Membr Biol. March 15, 2003; 192 (2): 111-22.

K(ATP) channel activity is required for hatching in Xenopus embryos., Cheng SM, Chen I, Levin M., Dev Dyn. December 1, 2002; 225 (4): 588-91.        

Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures., Wu J, Xu H, Yang Z, Wang Y, Mao J, Jiang C., J Membr Biol. November 15, 2002; 190 (2): 105-16.

Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP., Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C., J Physiol. September 1, 2002; 543 (Pt 2): 495-504.

The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener., Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P., Diabetes. June 1, 2002; 51 (6): 1896-906.

Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP., Li L, Geng X, Drain P., J Gen Physiol. January 1, 2002; 119 (1): 105-16.                    

Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel., Xu H, Wu J, Cui N, Abdulkadir L, Wang R, Mao J, Giwa LR, Chanchevalap S, Jiang C., J Biol Chem. October 19, 2001; 276 (42): 38690-6.

Amiloride derivatives are potent blockers of KATP channels., Bollensdorff C, Zimmer T, Benndorf K., Naunyn Schmiedebergs Arch Pharmacol. October 1, 2001; 364 (4): 351-8.

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel., Proks P, Capener CE, Jones P, Ashcroft FM., J Gen Physiol. October 1, 2001; 118 (4): 341-53.                    

Structural basis for the interference between nicorandil and sulfonylurea action., Reimann F, Ashcroft FM, Gribble FM., Diabetes. October 1, 2001; 50 (10): 2253-9.

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH., Piao H, Cui N, Xu H, Mao J, Rojas A, Wang R, Abdulkadir L, Li L, Wu J, Jiang C., J Biol Chem. September 28, 2001; 276 (39): 36673-80.

Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism., Partridge CJ, Beech DJ, Sivaprasadarao A., J Biol Chem. September 21, 2001; 276 (38): 35947-52.

Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Song DK, Ashcroft FM., Br J Pharmacol. May 1, 2001; 133 (1): 193-9.

Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP., Krauter T, Ruppersberg JP, Baukrowitz T., Mol Pharmacol. May 1, 2001; 59 (5): 1086-93.

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel., Reimann F, Proks P, Ashcroft FM., Br J Pharmacol. April 1, 2001; 132 (7): 1542-8.

Interaction of stilbene disulphonates with cloned K(ATP) channels., Proks P, Jones P, Ashcroft FM., Br J Pharmacol. March 1, 2001; 132 (5): 973-82.

Direct interaction of Na-azide with the KATP channel., Trapp S, Ashcroft FM., Br J Pharmacol. November 1, 2000; 131 (6): 1105-12.

Identification of molecular regions responsible for the membrane trafficking of Kir6.2., Hough E, Beech DJ, Sivaprasadarao A., Pflugers Arch. July 1, 2000; 440 (3): 481-7.

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide., Tanabe K, Tucker SJ, Ashcroft FM, Proks P, Kioka N, Amachi T, Ueda K., Biochem Biophys Res Commun. June 7, 2000; 272 (2): 316-9.

Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone., McKay NG, Kinsella JM, Campbell CM, Ashford ML., Br J Pharmacol. June 1, 2000; 130 (4): 857-66.

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A., Gribble FM, Reimann F, Ashfield R, Ashcroft FM., Mol Pharmacol. June 1, 2000; 57 (6): 1256-61.

Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., Sakura H, Trapp S, Liss B, Ashcroft FM., J Physiol. December 1, 1999; 521 Pt 2 337-50.

In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound., Le Brigand L, Virsolvy A, Manechez D, Godfroid JJ, Guardiola-Lemaître B, Gribble FM, Ashcroft FM, Bataille D., Br J Pharmacol. November 1, 1999; 128 (5): 1021-6.

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP., Reimann F, Ryder TJ, Tucker SJ, Ashcroft FM., J Physiol. November 1, 1999; 520 Pt 3 661-9.

Interaction of vanadate with the cloned beta cell K(ATP) channel., Proks P, Ashfield R, Ashcroft FM., J Biol Chem. September 3, 1999; 274 (36): 25393-7.

PKA-mediated phosphorylation of the human K(ATP) channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation., Béguin P, Nagashima K, Nishimura M, Gonoi T, Seino S., EMBO J. September 1, 1999; 18 (17): 4722-32.

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor., Reimann F, Tucker SJ, Proks P, Ashcroft FM., J Physiol. July 15, 1999; 518 ( Pt 2) 325-36.

Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide., Gribble FM, Ashcroft FM., Diabetologia. July 1, 1999; 42 (7): 845-8.

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels., Zerangue N, Schwappach B, Jan YN, Jan LY., Neuron. March 1, 1999; 22 (3): 537-48.

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP., Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K., J Biol Chem. February 12, 1999; 274 (7): 3931-3.

A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland., Otonkoski T, Ammälä C, Huopio H, Cote GJ, Chapman J, Cosgrove K, Ashfield R, Huang E, Komulainen J, Ashcroft FM, Dunne MJ, Kere J, Thomas PM., Diabetes. February 1, 1999; 48 (2): 408-15.

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP., Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM., J Physiol. January 1, 1999; 514 ( Pt 1) 19-25.

KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit., Drain P, Li L, Wang J., Proc Natl Acad Sci U S A. November 10, 1998; 95 (23): 13953-8.

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA., Gribble FM, Proks P, Corkey BE, Ashcroft FM., J Biol Chem. October 9, 1998; 273 (41): 26383-7.

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP., Trapp S, Proks P, Tucker SJ, Ashcroft FM., J Gen Physiol. September 1, 1998; 112 (3): 333-49.                

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification., Trapp S, Tucker SJ, Ashcroft FM., J Gen Physiol. September 1, 1998; 112 (3): 325-32.          

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit., Gribble FM, Tucker SJ, Haug T, Ashcroft FM., Proc Natl Acad Sci U S A. June 9, 1998; 95 (12): 7185-90.

Phentolamine block of KATP channels is mediated by Kir6.2., Proks P, Ashcroft FM., Proc Natl Acad Sci U S A. October 14, 1997; 94 (21): 11716-20.

The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation., Gribble FM, Tucker SJ, Ashcroft FM., J Physiol. October 1, 1997; 504 ( Pt 1) 35-45.

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits., Trapp S, Tucker SJ, Ashcroft FM., Proc Natl Acad Sci U S A. August 5, 1997; 94 (16): 8872-7.

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor., Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM., Nature. May 8, 1997; 387 (6629): 179-83.

Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes., Gribble FM, Ashfield R, Ammälä C, Ashcroft FM., J Physiol. January 1, 1997; 498 ( Pt 1) 87-98.

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro., Sakura H, Wat N, Horton V, Millns H, Turner RC, Ashcroft FM., Diabetologia. October 1, 1996; 39 (10): 1233-6.

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