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Summary Expression Phenotypes Gene Literature (192) GO Terms (6) Nucleotides (126) Proteins (56) Interactants (656) Wiki
XB--487965

Papers associated with nkx2-5



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Characterization of Xenopus Phox2a and Phox2b defines expression domains within the embryonic nervous system and early heart field., Talikka M, Stefani G, Brivanlou AH, Zimmerman K., Gene Expr Patterns. September 1, 2004; 4 (5): 601-7.      

Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis., Ueyama T, Kasahara H, Ishiwata T, Nie Q, Izumo S., Mol Cell Biol. December 1, 2003; 23 (24): 9222-32.

NKX2.5 mutations in patients with congenital heart disease., McElhinney DB, Geiger E, Blinder J, Benson DW, Goldmuntz E., J Am Coll Cardiol. November 5, 2003; 42 (9): 1650-5.

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart., Stennard FA, Costa MW, Elliott DA, Rankin S, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP., Dev Biol. October 15, 2003; 262 (2): 206-24.  

Amphibian in vitro heart induction: a simple and reliable model for the study of vertebrate cardiac development., Ariizumi T, Kinoshita M, Yokota C, Takano K, Fukuda K, Moriyama N, Malacinski GM, Asashima M., Int J Dev Biol. September 1, 2003; 47 (6): 405-10.      

The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)., Nagel S, Kaufmann M, Drexler HG, MacLeod RA., Cancer Res. September 1, 2003; 63 (17): 5329-34.

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF., Small EM, Krieg PA., Dev Biol. September 1, 2003; 261 (1): 116-31.          

Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5., Funke-Kaiser H, Lemmer J, Langsdorff CV, Thomas A, Kovacevic SD, Strasdat M, Behrouzi T, Zollmann FS, Paul M, Orzechowski HD., FASEB J. August 1, 2003; 17 (11): 1487-9.

Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart., Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S., J Biol Chem. August 1, 2003; 278 (31): 28750-7.

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5., Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D., Nature. July 24, 2003; 424 (6947): 443-7.

PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5., Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA., J Biol Chem. June 20, 2003; 278 (25): 22437-45.

Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome., Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP., J Am Coll Cardiol. June 4, 2003; 41 (11): 2072-6.

Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity., Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ., Genesis. April 1, 2003; 35 (4): 220-6.

Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells., Hidaka K, Lee JK, Lee JK, Kim HS, Ihm CH, Iio A, Ogawa M, Nishikawa S, Kodama I, Morisaki T., FASEB J. April 1, 2003; 17 (6): 740-2.

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes., Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S., J Mol Cell Cardiol. March 1, 2003; 35 (3): 243-56.

Too much Csx/Nkx2-5 is as bad as too little?, Akazawa H, Komuro I., J Mol Cell Cardiol. March 1, 2003; 35 (3): 227-9.

Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD., Watanabe Y, Benson DW, Yano S, Akagi T, Yoshino M, Murray JC., J Med Genet. November 1, 2002; 39 (11): 807-11.

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene., Thattaliyath BD, Firulli BA, Firulli AB., J Mol Cell Cardiol. October 1, 2002; 34 (10): 1335-44.

Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors., Kodama H, Hirotani T, Suzuki Y, Ogawa S, Yamazaki K., Am J Pathol. August 1, 2002; 161 (2): 381-9.

Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity., Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ., J Biol Chem. July 12, 2002; 277 (28): 25775-82.

Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart., Toko H, Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I., J Biol Chem. July 5, 2002; 277 (27): 24735-43.

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5., Wakimoto H, Kasahara H, Maguire CT, Izumo S, Berul CI., J Cardiovasc Electrophysiol. July 1, 2002; 13 (7): 682-8.

The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis., Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y., J Clin Invest. July 1, 2002; 110 (2): 177-84.

Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor., Müller JG, Thompson JT, Edmonson AM, Rackley MS, Kasahara H, Izumo S, McQuinn TC, Menick DR, O'Brien TX., J Mol Cell Cardiol. July 1, 2002; 34 (7): 807-21.

A role for the RNA-binding protein, hermes, in the regulation of heart development., Gerber WV, Vokes SA, Zearfoss NR, Krieg PA., Dev Biol. July 1, 2002; 247 (1): 116-26.    

Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease., Ikeda Y, Hiroi Y, Hosoda T, Utsunomiya T, Matsuo S, Ito T, Inoue J, Sumiyoshi T, Takano H, Nagai R, Komuro I., Circ J. June 1, 2002; 66 (6): 561-3.

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation., Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM., Genes Dev. May 15, 2002; 16 (10): 1234-46.

Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site., Lien CL, McAnally J, Richardson JA, Olson EN., Dev Biol. April 15, 2002; 244 (2): 257-66.

Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region., Liberatore CM, Searcy-Schrick RD, Vincent EB, Yutzey KE., Dev Biol. April 15, 2002; 244 (2): 243-56.

A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5., Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S., Cold Spring Harb Symp Quant Biol. January 1, 2002; 67 317-25.

Homeodomain factor Nkx2-5 in heart development and disease., Harvey RP, Lai D, Elliott D, Biben C, Solloway M, Prall O, Stennard F, Schindeler A, Groves N, Lavulo L, Hyun C, Yeoh T, Costa M, Furtado M, Kirk E., Cold Spring Harb Symp Quant Biol. January 1, 2002; 67 107-14.

Developmental paradigms in heart disease: insights from tinman., Prall OW, Elliott DA, Harvey RP., Ann Med. January 1, 2002; 34 (3): 148-56.

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice., Moses KA, DeMayo F, Braun RM, Reecy JL, Schwartz RJ., Genesis. December 1, 2001; 31 (4): 176-80.

BMP signaling regulates Nkx2-5 activity during cardiomyogenesis., Jamali M, Karamboulas C, Rogerson PJ, Skerjanc IS., FEBS Lett. November 30, 2001; 509 (1): 126-30.

NKX2.5 mutations in patients with tetralogy of fallot., Goldmuntz E, Geiger E, Benson DW., Circulation. November 20, 2001; 104 (21): 2565-8.

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation., Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D., Dev Biol. November 15, 2001; 239 (2): 190-203.

Nkx2-5 activity is essential for cardiomyogenesis., Jamali M, Rogerson PJ, Wilton S, Skerjanc IS., J Biol Chem. November 9, 2001; 276 (45): 42252-8.

Endoderm specification and differentiation in Xenopus embryos., Horb ME, Slack JM., Dev Biol. August 15, 2001; 236 (2): 330-43.                

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein., Kasahara H, Wakimoto H, Liu M, Maguire CT, Converso KL, Shioi T, Huang WY, Manning WJ, Paul D, Lawitts J, Berul CI, Izumo S., J Clin Invest. July 1, 2001; 108 (2): 189-201.

Elevated expression of Nkx-2.5 in developing myocardial conduction cells., Thomas PS, Kasahara H, Edmonson AM, Izumo S, Yacoub MH, Barton PJ, Gourdie RG., Anat Rec. July 1, 2001; 263 (3): 307-13.

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation., Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I., Nat Genet. July 1, 2001; 28 (3): 276-80.

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx., Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S., Mol Cell Biol. July 1, 2001; 21 (13): 4391-8.

Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5., Reiter JF, Verkade H, Stainier DY., Dev Biol. June 15, 2001; 234 (2): 330-8.

Twisted gastrulation can function as a BMP antagonist., Chang C, Holtzman DA, Chau S, Chickering T, Woolf EA, Holmgren LM, Bodorova J, Gearing DP, Holmes WE, Brivanlou AH., Nature. March 22, 2001; 410 (6827): 483-7.

Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein., Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S., J Biol Chem. February 16, 2001; 276 (7): 4570-80.

Inhibition of Wnt activity induces heart formation from posterior mesoderm., Marvin MJ, Di Rocco G, Gardiner A, Bush SM, Lassar AB., Genes Dev. February 1, 2001; 15 (3): 316-27.  

COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development., Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M., J Biol Chem. January 26, 2001; 276 (4): 2797-801.

Factors in serum regulate Nkx2.5 and MEF2C function., Jamali M, Karamboulas C, Wilton S, Skerjanc IS., In Vitro Cell Dev Biol Anim. January 1, 2001; 37 (10): 635-7.

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5., Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott DA, Barnett L, Köentgen F, Robb L, Feneley M, Harvey RP., Circ Res. November 10, 2000; 87 (10): 888-95.

Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease., Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I., J Biol Chem. November 10, 2000; 275 (45): 35291-6.

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