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Summary Expression Phenotypes Gene Literature (91) GO Terms (2) Nucleotides (206) Proteins (91) Interactants (305) Wiki
XB-GENEPAGE-479124

Papers associated with slc4a4



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referenced by:

Normal Table of Xenopus development: a new graphical resource., Zahn N, James-Zorn C, Ponferrada VG, Adams DS, Grzymkowski J, Buchholz DR, Nascone-Yoder NM, Horb M, Moody SA, Vize PD, Zorn AM., Development. July 15, 2022; 149 (14):                         

Molecular insight into coordination sites for substrates and their coupling kinetics in Na+ /HCO3 - cotransporter NBCe1., Wu H, Liu S, Su P, Xie ZD, Gui TX, Zhao L, Liu Y, Chen LM., J Physiol. July 1, 2022; 600 (13): 3083-3111.

Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles., Ta AC, Huang LC, McKeown CR, Bestman JE, Van Keuren-Jensen K, Cline HT., G3 (Bethesda). January 4, 2022; 12 (1):               

Lack of Charge Interaction in the Ion Binding Site Determines Anion Selectivity in the Sodium Bicarbonate Cotransporter NBCe1., Lee S, Lin J, Choi I., Int J Mol Sci. January 4, 2022; 23 (1):


A novel I551F variant of the Na+/HCO3- cotransporter NBCe1-A shows reduced cell surface expression, resulting in diminished transport activity., Yamazaki O, Yamashita M, Li J, Ochiai-Homma F, Yoshida T, Hirahashi J, Furukawa T, Kozuma K, Fujigaki Y, Seki G, Hayashi M, Shibata S., Am J Physiol Renal Physiol. December 1, 2021; 321 (6): F771-F784.

Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na+/qHCO3- Cotransporter NBCe1., Alsufayan TA, Myers EJ, Quade BN, Brady CT, Marshall A, Haque N, Duffey ME, Parker MD., Int J Mol Sci. November 26, 2021; 22 (23):                         

Carbonic anhydrases enhance activity of endogenous Na-H exchangers and not the electrogenic Na/HCO3 cotransporter NBCe1-A, expressed in Xenopus oocytes., Moss FJ, Boron WF., J Physiol. December 1, 2020; 598 (24): 5821-5856.

The devil is in the C-tail: a NBCe1-carbonic anhydrase bicarbonate transport metabolon?, Praetorius J., J Physiol. December 1, 2020; 598 (24): 5595-5596.

Activation of mouse NBCe1-B by Xenopus laevis and mouse IRBITs: Role of the variable Nt appendage of IRBITs., Wang M, Wu H, Liu Y, Chen LM., Biochim Biophys Acta Biomembr. June 1, 2020; 1862 (6): 183240.

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis., Deitmer JW, Theparambil SM, Ruminot I, Noor SI, Becker HM., Front Neurosci. March 15, 2019; 13 1301.  

Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT., Vachel L, Shcheynikov N, Yamazaki O, Fremder M, Ohana E, Son A, Shin DM, Yamazaki-Nakazawa A, Yang CR, Knepper MA, Muallem S., Sci Signal. October 30, 2018; 11 (554):


Exploring the autoinhibitory domain of the electrogenic Na+ /HCO3- transporter NBCe1-B, from residues 28 to 62., Lee SK, Boron WF., J Physiol. August 1, 2018; 596 (16): 3637-3653.

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney., Zhang B, Tran U, Wessely O., Development. March 22, 2018; 145 (6):                         

The role of disease-linked residue glutamine-913 in support of the structure and function of the human electrogenic sodium/bicarbonate cotransporter NBCe1-A., Myers EJ, Marshall A, Parker MD., Sci Rep. February 15, 2018; 8 (1): 3066.                    

Bicarbonate sensing in mouse cortical astrocytes during extracellular acid/base disturbances., Theparambil SM, Naoshin Z, Defren S, Schmaelzle J, Weber T, Schneider HP, Deitmer JW., J Physiol. April 15, 2017; 595 (8): 2569-2585.

Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins., Kawaai K, Ando H, Satoh N, Yamada H, Ogawa N, Hirose M, Mizutani A, Bonneau B, Seki G, Mikoshiba K., Proc Natl Acad Sci U S A. April 11, 2017; 114 (15): 3921-3926.                          

A novel mutant Na + /HCO3 - cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis., Myers EJ, Yuan L, Felmlee MA, Lin YY, Jiang Y, Pei Y, Wang O, Li M, Xing XP, Marshall A, Xia WB, Parker MD., J Physiol. November 1, 2016; 594 (21): 6267-6286.

Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859., Heidtmann H, Ruminot I, Becker HM, Deitmer JW., Eur J Pharmacol. September 5, 2015; 762 344-9.

High effective cytosolic H+ buffering in mouse cortical astrocytes attributable to fast bicarbonate transport., Theparambil SM, Deitmer JW., Glia. September 1, 2015; 63 (9): 1581-94.

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes., Theparambil SM, Naoshin Z, Thyssen A, Deitmer JW., J Physiol. August 15, 2015; 593 (16): 3533-47.

Phosphatidylinositol 4,5-bisphosphate degradation inhibits the Na+/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus oocytes., Thornell IM, Bevensee MO., J Physiol. February 1, 2015; 593 (3): 541-58.

Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development., Buisson I, Le Bouffant R, Futel M, Riou JF, Umbhauer M., Dev Biol. January 15, 2015; 397 (2): 175-90.                            

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function., Jamali S, Klier M, Ames S, Barros LF, McKenna R, Deitmer JW, Becker HM., Sci Rep. January 12, 2015; 5 13605.              

NBCe1A dimer assemble visualized by bimolecular fluorescence complementation., Chang MH, Chen AP, Romero MF., Am J Physiol Renal Physiol. March 15, 2014; 306 (6): F672-80.

The electrogenic sodium bicarbonate cotransporter NBCe1 is a high-affinity bicarbonate carrier in cortical astrocytes., Theparambil SM, Ruminot I, Schneider HP, Shull GE, Deitmer JW., J Neurosci. January 22, 2014; 34 (4): 1148-57.

Identification of dominant negative effect of L522P mutation in the electrogenic Na⁺-HCO₃⁻ cotransporter NBCe1., Yamazaki O, Yamada H, Suzuki M, Horita S, Shirai A, Nakamura M, Satoh N, Fujita T, Seki G., Pflugers Arch. September 1, 2013; 465 (9): 1281-91.

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3., Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS., Nat Genet. August 1, 2013; 45 (8): 951-6.                                

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation., Streets AJ, Wessely O, Peters DJ, Ong AC., Hum Mol Genet. May 15, 2013; 22 (10): 1924-39.

Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits., Lee SK, Boron WF, Parker MD., Am J Physiol Renal Physiol. April 1, 2013; 304 (7): F883-99.

Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1., Bae JS, Koo NY, Namkoong E, Davies AJ, Choi SK, Shin Y, Jin M, Hwang SM, Mikoshiba K, Park K., J Biol Chem. March 1, 2013; 288 (9): 6295-305.

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2., Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyryläinen R, Shan J, Vainio S, Umbhauer M, Cereghini S., Development. February 1, 2013; 140 (4): 873-85.  

PIP2 hydrolysis stimulates the electrogenic Na+-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes., Thornell IM, Wu J, Liu X, Bevensee MO., J Physiol. December 1, 2012; 590 (23): 5993-6011.

The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane., Li HC, Kucher V, Li EY, Conforti L, Zahedi KA, Soleimani M., Am J Physiol Cell Physiol. June 15, 2012; 302 (12): C1713-30.

Euryhaline pufferfish NBCe1 differs from nonmarine species NBCe1 physiology., Chang MH, Plata C, Kurita Y, Kato A, Hirose S, Romero MF., Am J Physiol Cell Physiol. April 15, 2012; 302 (8): C1083-95.

HCO(3)(-)-independent conductance with a mutant Na(+)/HCO(3)(-) cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis., Parker MD, Qin X, Williamson RC, Toye AM, Boron WF., J Physiol. April 15, 2012; 590 (8): 2009-34.

Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes., Chen LM, Qin X, Moss FJ, Liu Y, Boron WF., J Membr Biol. March 1, 2012; 245 (3): 131-40.

Relief of autoinhibition of the electrogenic Na-HCO(3) [corrected] cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation., Lee SK, Boron WF, Parker MD., Am J Physiol Cell Physiol. February 1, 2012; 302 (3): C518-26.

Xenopus as a model system for the study of GOLPH2/GP73 function: Xenopus GOLPH2 is required for pronephros development., Li L, Wen L, Gong Y, Mei G, Liu J, Chen Y, Peng T., PLoS One. January 1, 2012; 7 (6): e38939.                                              

Role of an extracellular loop in determining the stoichiometry of Na+-HCO₃⁻ cotransporters., Chen LM, Liu Y, Boron WF., J Physiol. February 15, 2011; 589 (Pt 4): 877-90.

Functional characterization of nonsynonymous single nucleotide polymorphisms in the electrogenic Na+-HCO3- cotransporter NBCe1A., Yamazaki O, Yamada H, Suzuki M, Horita S, Shirai A, Nakamura M, Seki G, Fujita T., Pflugers Arch. February 1, 2011; 461 (2): 249-59.

Functional role of a putative carbonic anhydrase II-binding domain in the electrogenic Na+ -HCO₃- cotransporter NBCe1 expressed in Xenopus oocytes., Yamada H, Horita S, Suzuki M, Fujita T, Seki G., Channels (Austin). January 1, 2011; 5 (2): 106-9.

Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase., Schueler C, Becker HM, McKenna R, Deitmer JW., PLoS One. January 1, 2011; 6 (11): e27167.                

Sharpey-Schafer lecture: gas channels., Boron WF., Exp Physiol. December 1, 2010; 95 (12): 1107-30.                      

Inversin relays Frizzled-8 signals to promote proximal pronephros development., Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schäfer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Krönig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, Walz G., Proc Natl Acad Sci U S A. November 23, 2010; 107 (47): 20388-93.                          

Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine., Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, De Jonghe P, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shiohara M, Braverman N, Al-Gazali L, Fujita T, Seki G., Proc Natl Acad Sci U S A. September 7, 2010; 107 (36): 15963-8.

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity., Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O., Development. April 1, 2010; 137 (7): 1107-16.              

Basolateral NBCe1 plays a rate-limiting role in transepithelial intestinal HCO3- secretion, contributing to marine fish osmoregulation., Taylor JR, Mager EM, Grosell M., J Exp Biol. February 1, 2010; 213 (3): 459-68.

The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1., Agrawal R, Tran U, Wessely O., Development. December 1, 2009; 136 (23): 3927-36.              

Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish., Sussman CR, Zhao J, Plata C, Lu J, Daly C, Angle N, DiPiero J, Drummond IA, Liang JO, Boron WF, Romero MF, Chang MH., Am J Physiol Cell Physiol. October 1, 2009; 297 (4): C865-75.

Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes., Wu J, McNicholas CM, Bevensee MO., Proc Natl Acad Sci U S A. August 18, 2009; 106 (33): 14150-5.

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