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Summary Expression Phenotypes Gene Literature (54) GO Terms (34) Nucleotides (417) Proteins (90) Interactants (548) Wiki
XB-GENEPAGE-479153

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The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.

Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits., Corradi E, Dalla Costa I, Gavoci A, Iyer A, Roccuzzo M, Otto TA, Oliani E, Bridi S, Strohbuecker S, Santos-Rodriguez G, Valdembri D, Serini G, Abreu-Goodger C, Baudet ML., EMBO J. March 16, 2020; 39 (6): e102513.                            

A Dual-App Nucleoside Probe Provides Structural Insights into the Human Telomeric Overhang in Live Cells., Manna S, Sarkar D, Srivatsan SG., J Am Chem Soc. October 3, 2018; 140 (39): 12622-12633.

Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine., Cobo R, Nikolaeva M, Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A., Front Mol Neurosci. February 7, 2018; 11 193.                    

Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway., Li S, Wang X, Ma QH, Yang WL, Zhang XG, Dawe GS, Xiao ZC., Sci Rep. December 23, 2016; 6 39320.                

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter., Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE., PLoS Pathog. July 21, 2016; 12 (7): e1005725.          

Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue., Incecayir T, Sun J, Tsume Y, Xu H, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL., J Pharm Sci. February 1, 2016; 105 (2): 925-934.

Roles of Aquaporins in Setaria viridis Stem Development and Sugar Storage., McGaughey SA, Osborn HL, Chen L, Pegler JL, Tyerman SD, Furbank RT, Byrt CS, Grof CP., Front Plant Sci. January 1, 2016; 7 1815.          

Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels., Vingtdeux V, Tanis JE, Chandakkar P, Zhao H, Dreses-Werringloer U, Campagne F, Foskett JK, Marambaud P., PLoS One. November 6, 2014; 9 (11): e112484.        

Modulation of human α4β2 nicotinic acetylcholine receptors by brominated and halogen-free flame retardants as a measure for in vitro neurotoxicity., Hendriks HS, van Kleef RG, Westerink RH., Toxicol Lett. September 3, 2012; 213 (2): 266-74.

4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter., Solis E, Zdravkovic I, Tomlinson ID, Noskov SY, Rosenthal SJ, De Felice LJ., J Biol Chem. March 16, 2012; 287 (12): 8852-63.

Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events., Winkler DD, Muthurajan UM, Hieb AR, Luger K., J Biol Chem. December 2, 2011; 286 (48): 41883-41892.            

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors., Borysov SI, Granic A, Padmanabhan J, Walczak CE, Potter H., Cell Cycle. May 1, 2011; 10 (9): 1397-410.

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production., Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM., J Cell Biol. June 30, 2008; 181 (7): 1107-16.                

Disparate effects of p24alpha and p24delta on secretory protein transport and processing., Strating JR, Bouw G, Hafmans TG, Martens GJ., PLoS One. August 8, 2007; 2 (8): e704.              

Endogenous C-terminal fragments of beta-amyloid precursor protein from Xenopus laevis skin exudate., Clamagirand C, El Abida B, Der Garabedian PA, Hanquez C, Dubost L, Marie A, Rholam M, Friguet B, Cohen P., Comp Biochem Physiol B Biochem Mol Biol. April 1, 2007; 146 (4): 530-9.

Quantification of Mg2+ extrusion and cytosolic Mg2+-buffering in Xenopus oocytes., Gabriel TE, Günzel D., Arch Biochem Biophys. February 1, 2007; 458 (1): 3-15.

The coding sequence of amyloid-beta precursor protein APP contains a neural-specific promoter element., Collin RW, Martens GJ., Dev Biol. May 4, 2006; 1087 (1): 41-51.            

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells., Lahiri DK, Maloney B, Ge YW., J Mol Neurosci. January 1, 2006; 29 (1): 65-80.

Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease., Maloney MT, Minamide LS, Kinley AW, Boyle JA, Bamburg JR., J Neurosci. December 7, 2005; 25 (49): 11313-21.

The amyloid-beta precursor-like protein APLP2 and its relative APP are differentially regulated during neuroendocrine cell activation., Collin RW, Martens GJ., Mol Cell Neurosci. November 1, 2005; 30 (3): 429-36.

Biosynthesis and differential processing of two pools of amyloid-beta precursor protein in a physiologically inducible neuroendocrine cell., Collin RW, van den Hurk WH, Martens GJ., J Neurochem. August 1, 2005; 94 (4): 1015-24.

Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease., Xiong H, McCabe L, Costello J, Anderson E, Weber G, Ikezu T., Neurobiol Aging. August 1, 2004; 25 (7): 905-11.

Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis., Collin RW, van Strien D, Leunissen JA, Martens GJ., Eur J Biochem. May 1, 2004; 271 (10): 1906-12.

High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein., Golemi-Kotra D, Mahaffy R, Footer MJ, Holtzman JH, Pollard TD, Theriot JA, Schepartz A., J Am Chem Soc. January 14, 2004; 126 (1): 4-5.

Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system., Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK., J Neurosci Res. July 15, 2003; 73 (2): 255-9.

Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity., Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H., J Neurochem. May 1, 2003; 85 (4): 925-34.

Evidence for a copper-binding superfamily of the amyloid precursor protein., Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, Masters CL, White AR, Cappai R, Beyreuther K, Bayer TA, Multhaup G., Biochemistry. July 30, 2002; 41 (30): 9310-20.

Carboxyl-terminal peptide of beta-amyloid precursor protein blocks inositol 1,4,5-trisphosphate-sensitive Ca2+ release in Xenopus laevis oocytes., Kim JH, Rah JC, Fraser SP, Chang KA, Djamgoz MB, Suh YH., J Biol Chem. June 7, 2002; 277 (23): 20256-63.

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein., White AR, Multhaup G, Galatis D, McKinstry WJ, Parker MW, Pipkorn R, Beyreuther K, Masters CL, Cappai R., J Neurosci. January 15, 2002; 22 (2): 365-76.

Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis., van den Hurk WH, Bloemen M, Martens GJ., Brain Res Mol Brain Res. December 16, 2001; 97 (1): 13-20.          

Presenilin 1 mutations increase amyloid precursor protein production and proteolysis in Xenopus laevis oocytes., Heyn SN, Vulliet PR., Dev Biol. June 22, 2001; 904 (2): 189-98.

Toxic effect of the beta-amyloid precursor protein C-terminus fragment and Na+/Ca2+ gradients., Bryan-Sisneros AA, Fraser SP, Suh YH, Djamgoz MB., Neuroreport. October 20, 2000; 11 (15): 3357-60.

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity., Kim HS, Park CH, Cha SH, Lee JH, Lee JH, Lee S, Kim Y, Rah JC, Jeong SJ, Suh YH., FASEB J. August 1, 2000; 14 (11): 1508-17.

A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins., Mbella EG, Bertrand S, Huez G, Octave JN., Mol Cell Biol. July 1, 2000; 20 (13): 4572-9.

APP carboxyl-terminal fragment without or with abeta domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons., Lee JP, Lee JP, Chang KA, Kim HS, Kim SS, Jeong SJ, Suh YH., J Neurosci Res. May 15, 2000; 60 (4): 565-70.

Adrenomedullin in nonmammalian vertebrate pancreas: an immunocytochemical study., López J, Cuesta N, Cuttitta F, Martínez A., Gen Comp Endocrinol. September 1, 1999; 115 (3): 309-22.          

Novel domain-specific actions of amyloid precursor protein on developing synapses., Morimoto T, Ohsawa I, Takamura C, Ishiguro M, Nakamura Y, Kohsaka S., J Neurosci. November 15, 1998; 18 (22): 9386-93.

Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine., Ritzel MW, Yao SY, Ng AM, Mackey JR, Cass CE, Young JD., Mol Membr Biol. January 1, 1998; 15 (4): 203-11.

Expression of the mammalian renal peptide transporter PEPT2 in the yeast Pichia pastoris and applications of the yeast system for functional analysis., Döring F, Michel T, Rösel A, Nickolaus M, Daniel H., Mol Membr Biol. January 1, 1998; 15 (2): 79-88.

Expression and functional characterization of the mammalian intestinal peptide transporter PepT1 in the methylotropic yeast Pichia pastoris., Döring F, Theis S, Daniel H., Biochem Biophys Res Commun. March 27, 1997; 232 (3): 656-62.

Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1., Steel A, Nussberger S, Romero MF, Boron WF, Boyd CA, Hediger MA., J Physiol. February 1, 1997; 498 ( Pt 3) 563-9.

Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer's amyloid precursor protein., Kim SH, Suh YH., J Neurochem. September 1, 1996; 67 (3): 1172-82.

Molecular physiology, biochemistry, and pharmacology of Alzheimer's amyloid precursor protein (APP)., Suh YH, Chong YH, Kim SH, Choi W, Min K, Jeong SJ, Fraser SP, Djamgoz MB., Ann N Y Acad Sci. June 15, 1996; 786 169-83.

Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the beta-amyloid precursor protein., Fraser SP, Suh YH, Chong YH, Djamgoz MB., J Neurochem. May 1, 1996; 66 (5): 2034-40.

Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases., Murayama Y, Takeda S, Yonezawa K, Giambarella U, Nishimoto I, Ogata E., Gerontology. January 1, 1996; 42 Suppl 1 2-11.

Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors., Cohen BN, Figl A, Quick MW, Labarca C, Davidson N, Lester HA., J Gen Physiol. June 1, 1995; 105 (6): 745-64.

Developmental regulation of Xenopus beta-amyloid precursor protein gene expression., Okado H, Okamoto H., Gerontology. January 1, 1995; 41 Suppl 1 7-12.

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl., Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S., Cell. July 1, 1994; 77 (7): 1117-24.

Activity of the E75E76 mutant of the alpha subunit of casein kinase II from Xenopus laevis., Gatica M, Jedlicki A, Allende CC, Allende JE., FEBS Lett. February 14, 1994; 339 (1-2): 93-6.

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