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Summary Expression Phenotypes Gene Literature (96) GO Terms (4) Nucleotides (125) Proteins (64) Interactants (438) Wiki
XB-GENEPAGE-479924

Papers associated with slc12a1



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HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes., Grand K, Stoltz M, Rizzo L, Röck R, Kaminski MM, Salinas G, Getwan M, Naert T, Pichler R, Lienkamp SS., J Am Soc Nephrol. March 1, 2023; 34 (3): 412-432.                          

The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos., Massé K, Bhamra S, Paroissin C, Maneta-Peyret L, Boué-Grabot E, Jones EA., Commun Biol. October 7, 2021; 4 (1): 1158.                                

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease., Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS., Proc Natl Acad Sci U S A. September 28, 2021; 118 (39):                                                   

Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome., Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F., J Am Soc Nephrol. March 1, 2021; 32 (3): 580-596.    

SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect., McNeill A, Iovino E, Mansard L, Vache C, Baux D, Bedoukian E, Cox H, Dean J, Goudie D, Kumar A, Newbury-Ecob R, Fallerini C, Renieri A, Lopergolo D, Mari F, Blanchet C, Willems M, Roux AF, Pippucci T, Delpire E., Brain. August 1, 2020; 143 (8): 2380-2387.

WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration., Pacheco-Alvarez D, Carrillo-Pérez DL, Mercado A, Leyva-Ríos K, Moreno E, Hernández-Mercado E, Castañeda-Bueno M, Vázquez N, Gamba G., Am J Physiol Cell Physiol. August 1, 2020; 319 (2): C371-C380.

Endocytic recycling of Na+ -K+ -Cl- cotransporter type 2: importance of exon 4., Marcoux AA, Slimani S, Tremblay LE, Frenette-Cotton R, Garneau AP, Isenring P., J Physiol. August 1, 2019; 597 (16): 4263-4276.

Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway., Marcoux AA, Slimani S, Tremblay LE, Frenette-Cotton R, Garneau AP, Isenring P., Am J Physiol Cell Physiol. July 1, 2019; 317 (1): C20-C30.

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy., Brandt C, Seja P, Töllner K, Römermann K, Hampel P, Kalesse M, Kipper A, Feit PW, Lykke K, Toft-Bertelsen TL, Paavilainen P, Spoljaric I, Puskarjov M, MacAulay N, Kaila K, Löscher W., Neuropharmacology. December 1, 2018; 143 186-204.

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney., Zhang B, Tran U, Wessely O., Development. March 22, 2018; 145 (6):                         

Geraniin is a diuretic by inhibiting the Na+-K+-2Cl- cotransporter NKCC2., Moreno E, Gayosso JA, Montejano JR, Almaguer G, Vázquez N, Cruz C, Mercado A, Bobadilla NA, Gamba G, Sierra A, Ramírez V., Am J Physiol Renal Physiol. February 1, 2018; 314 (2): F240-F250.

lrpap1 as a specific marker of proximal pronephric kidney tubuli in Xenopus laevis embryos., Neuhaus H, Gaul F, Hollemann T., Int J Dev Biol. January 1, 2018; 62 (4-5): 319-324.          

Renal localization and regulation by dietary phosphate of the MCT14 orphan transporter., Knöpfel T, Atanassoff A, Hernando N, Biber J, Wagner CA., PLoS One. June 29, 2017; 12 (6): e0177942.          

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters., Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G., Am J Physiol Cell Physiol. July 1, 2016; 311 (1): C54-66.

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation., Murthy M, Kurz T, O'Shaughnessy KM., Physiol Rep. July 1, 2016; 4 (13):             

The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A., Lykke K, Töllner K, Feit PW, Erker T, MacAulay N, Löscher W., Epilepsy Behav. June 1, 2016; 59 42-9.

Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter., Lykke K, Töllner K, Römermann K, Feit PW, Erker T, MacAulay N, Löscher W., Br J Pharmacol. September 1, 2015; 172 (18): 4469-4480.

Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development., Buisson I, Le Bouffant R, Futel M, Riou JF, Umbhauer M., Dev Biol. January 15, 2015; 397 (2): 175-90.                            

Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage., Markadieu N, Rios K, Spiller BW, McDonald WH, Welling PA, Delpire E., J Biol Chem. October 17, 2014; 289 (42): 29273-84.

Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts., Cerqueira DM, Tran U, Romaker D, Abreu JG, Wessely O., Dev Biol. October 1, 2014; 394 (1): 54-64.                                          

The Wnt/JNK signaling target gene alcam is required for embryonic kidney development., Cizelsky W, Tata A, Kühl M, Kühl SJ., Development. May 1, 2014; 141 (10): 2064-74.          

MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney., Romaker D, Kumar V, Cerqueira DM, Cox RM, Wessely O., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): 6335-40.                                                          

Functional consequences of NKCC2 splice isoforms: insights from a Xenopus oocyte model., Lu L, Fraser JA., Am J Physiol Renal Physiol. April 1, 2014; 306 (7): F710-20.

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension., Picard N, Trompf K, Yang CL, Miller RL, Carrel M, Loffing-Cueni D, Fenton RA, Ellison DH, Loffing J., J Am Soc Nephrol. March 1, 2014; 25 (3): 511-22.

SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1., Elvira B, Munoz C, Borras J, Chen H, Warsi J, Ajay SS, Shumilina E, Lang F., Kidney Blood Press Res. January 1, 2014; 39 (4): 353-60.

Differential expression of arid5b isoforms in Xenopus laevis pronephros., Le Bouffant R, Cunin AC, Buisson I, Cartry J, Riou JF, Umbhauer M., Int J Dev Biol. January 1, 2014; 58 (5): 363-8.                

Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2., Park HJ, Curry JN, McCormick JA., Am J Physiol Renal Physiol. December 15, 2013; 305 (12): F1687-96.

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling., Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G., J Biol Chem. November 1, 2013; 288 (44): 31468-76.            

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3., Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS., Nat Genet. August 1, 2013; 45 (8): 951-6.                                

Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros., Zhang B, Romaker D, Ferrell N, Wessely O., Dev Biol. April 1, 2013; 376 (1): 31-42.                        

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2., Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyryläinen R, Shan J, Vainio S, Umbhauer M, Cereghini S., Development. February 1, 2013; 140 (4): 873-85.  

Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites., Na T, Wu G, Zhang W, Dong WJ, Peng JB., Am J Physiol Renal Physiol. January 1, 2013; 304 (1): F8-F18.

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers., Ponce-Coria J, Gagnon KB, Delpire E., Am J Physiol Cell Physiol. December 1, 2012; 303 (11): C1198-205.

Aquaporin-2: new mutations responsible for autosomal-recessive nephrogenic diabetes insipidus-update and epidemiology., Bichet DG, El Tarazi A, Matar J, Lussier Y, Arthus MF, Lonergan M, Bockenhauer D, Bissonnette P., Clin Kidney J. June 1, 2012; 5 (3): 195-202.          

Cotransport of water by Na⁺-K⁺-2Cl⁻ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2., Zeuthen T, Macaulay N., J Physiol. March 1, 2012; 590 (5): 1139-54.

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S., Biol Open. February 15, 2012; 1 (2): 120-7.              

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family., Pacheco-Alvarez D, Vázquez N, Castañeda-Bueno M, de-Los-Heros P, Cortes-González C, Moreno E, Meade P, Bobadilla NA, Gamba G., Cell Physiol Biochem. January 1, 2012; 29 (1-2): 291-302.

Xenopus as a model system for the study of GOLPH2/GP73 function: Xenopus GOLPH2 is required for pronephros development., Li L, Wen L, Gong Y, Mei G, Liu J, Chen Y, Peng T., PLoS One. January 1, 2012; 7 (6): e38939.                                              

Kinetics of hyperosmotically stimulated Na-K-2Cl cotransporter in Xenopus laevis oocytes., Delpire E, Gagnon KB., Am J Physiol Cell Physiol. November 1, 2011; 301 (5): C1074-85.

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner., Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Raffi H, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castañeda-Bueno M, Gamba G, Bachmann S., J Biol Chem. August 26, 2011; 286 (34): 30200-10.

Rare mutations in the human Na-K-Cl cotransporter (NKCC2) associated with lower blood pressure exhibit impaired processing and transport function., Monette MY, Rinehart J, Lifton RP, Forbush B., Am J Physiol Renal Physiol. April 1, 2011; 300 (4): F840-7.

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models., Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL., Hum Mol Genet. March 1, 2011; 20 (5): 855-66.

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters., Acuña R, Martínez-de-la-Maza L, Ponce-Coria J, Vázquez N, Ortal-Vite P, Pacheco-Alvarez D, Bobadilla NA, Gamba G., J Hypertens. March 1, 2011; 29 (3): 475-83.

Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development., Pegoraro C, Pollet N, Monsoro-Burq AH., Gene Expr Patterns. January 1, 2011; 11 (1-2): 122-8.    

WNK3 is a putative chloride-sensing kinase., Pacheco-Alvarez D, Gamba G., Cell Physiol Biochem. January 1, 2011; 28 (6): 1123-34.

Inversin relays Frizzled-8 signals to promote proximal pronephros development., Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schäfer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Krönig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, Walz G., Proc Natl Acad Sci U S A. November 23, 2010; 107 (47): 20388-93.                          

Molecular determinants of hyperosmotically activated NKCC1-mediated K+/K+ exchange., Gagnon KB, Delpire E., J Physiol. September 15, 2010; 588 (Pt 18): 3385-96.

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity., Gagnon KB, Delpire E., Am J Physiol Cell Physiol. September 1, 2010; 299 (3): C614-20.

Localization and functional characterization of the human NKCC2 isoforms., Carota I, Theilig F, Oppermann M, Kongsuphol P, Rosenauer A, Schreiber R, Jensen BL, Walter S, Kunzelmann K, Castrop H., Acta Physiol (Oxf). July 1, 2010; 199 (3): 327-38.

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