Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (147) GO Terms (6) Nucleotides (164) Proteins (70) Interactants (1267) Wiki
XB-GENEPAGE-482491

Papers associated with pitx2



???displayGene.coCitedPapers???
22 ???displayGene.morpholinoPapers???

???pagination.result.count???

???pagination.result.page??? 1 2 3 ???pagination.result.next???

Sort Newest To Oldest Sort Oldest To Newest

Pitx2 determines left-right asymmetry of internal organs in vertebrates., Ryan AK, Blumberg B, Rodriguez-Esteban C, Yonei-Tamura S, Tamura K, Tamura K, Tsukui T, de la Peña J, Sabbagh W, Greenwald J, Choe S, Norris DP, Robertson EJ, Evans RM, Rosenfeld MG, Izpisúa Belmonte JC., Nature. August 6, 1998; 394 (6693): 545-51.

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning., Gawantka V, Pollet N, Delius H, Vingron M, Pfister R, Nitsch R, Blumenstock C, Niehrs C., Mech Dev. October 1, 1998; 77 (2): 95-141.                                                            

Molecular mechanisms of vertebrate left-right development., Ramsdell AF, Yost HJ., Trends Genet. November 1, 1998; 14 (11): 459-65.

The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping., Campione M, Steinbeisser H, Schweickert A, Deissler K, van Bebber F, Lowe LA, Nowotschin S, Viebahn C, Haffter P, Kuehn MR, Blum M., Development. March 1, 1999; 126 (6): 1225-34.            

Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis., Chazaud C, Chambon P, Dollé P., Development. June 1, 1999; 126 (12): 2589-96.

The SIL gene is required for mouse embryonic axial development and left-right specification., Izraeli S, Lowe LA, Bertness VL, Good DJ, Dorward DW, Kirsch IR, Kuehn MR., Nature. June 17, 1999; 399 (6737): 691-4.

Cerberus regulates left-right asymmetry of the embryonic head and heart., Zhu L, Marvin MJ, Gardiner A, Lassar AB, Mercola M, Stern CD, Levin M., Curr Biol. September 9, 1999; 9 (17): 931-8.

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis., Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisúa-Belmonte JC, Rosenfeld MG., Nature. September 16, 1999; 401 (6750): 279-82.

Embryonic origins of spleen asymmetry., Patterson KD, Drysdale TA, Krieg PA., Development. January 1, 2000; 127 (1): 167-75.            

Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry., Schweickert A, Campione1 M, Steinbeisser H, Blum M., Mech Dev. January 1, 2000; 90 (1): 41-51.  

Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms., Essner JJ, Branford WW, Zhang J, Yost HJ., Development. March 1, 2000; 127 (5): 1081-93.      

The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus., Cheng AM, Thisse B, Thisse C, Wright CV., Development. March 1, 2000; 127 (5): 1049-61.                

More than 95% reversal of left-right axis induced by right-sided hypodermic microinjection of activin into Xenopus neurula embryos., Toyoizumi R, Mogi K, Takeuchi S., Dev Biol. May 15, 2000; 221 (2): 321-36.                

Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling., Branford WW, Essner JJ, Yost HJ., Dev Biol. July 15, 2000; 223 (2): 291-306.              

Zic3 is involved in the left-right specification of the Xenopus embryo., Kitaguchi T, Nagai T, Nakata K, Aruga J, Mikoshiba K., Development. November 1, 2000; 127 (22): 4787-95.              

Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2., Shiratori H, Sakuma R, Watanabe M, Hashiguchi H, Mochida K, Sakai Y, Nishino J, Saijoh Y, Whitman M, Hamada H., Mol Cell. January 1, 2001; 7 (1): 137-49.

The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. ., Faucourt M, Houliston E, Besnardeau L, Kimelman D, Lepage T., Dev Biol. January 15, 2001; 229 (2): 287-306.                

A role for BMP signalling in heart looping morphogenesis in Xenopus., Breckenridge RA, Mohun TJ, Amaya E., Dev Biol. April 1, 2001; 232 (1): 191-203.          

Pitx1 and Pitx2c are required for ectopic cement gland formation in Xenopus laevis., Schweickert A, Deissler K, Blum M, Steinbeisser H., Genesis. July 1, 2001; 30 (3): 144-8.        

Differential gene expression of Xenopus Pitx1, Pitx2b and Pitx2c during cement gland, stomodeum and pituitary development., Schweickert A, Steinbeisser H, Blum M., Mech Dev. September 1, 2001; 107 (1-2): 191-4.    

Calmodulin binds to inv protein: implication for the regulation of inv function., Yasuhiko Y, Imai F, Ookubo K, Takakuwa Y, Shiokawa K, Yokoyama T., Dev Growth Differ. December 1, 2001; 43 (6): 671-81.                

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor., Kramer KL, Yost HJ., Dev Cell. January 1, 2002; 2 (1): 115-24.  

Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry., Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K., Dev Growth Differ. February 1, 2002; 44 (1): 55-61.        

Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structures., Linask KK, Yu X, Chen Y, Han MD., Dev Biol. June 15, 2002; 246 (2): 407-17.

Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning., Levin M, Thorlin T, Robinson KR, Nogi T, Mercola M., Cell. October 4, 2002; 111 (1): 77-89.              

Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions., Liu C, Liu W, Palie J, Lu MF, Brown NA, Martin JF., Development. November 1, 2002; 129 (21): 5081-91.

PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development., Kramer KL, Barnette JE, Yost HJ., Cell. December 27, 2002; 111 (7): 981-90.                

Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein., Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R., Int J Dev Biol. February 1, 2003; 47 (1): 15-29.                  

Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin., Suszko MI, Lo DJ, Suh H, Camper SA, Woodruff TK., Mol Endocrinol. March 1, 2003; 17 (3): 318-32.

PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5., Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA., J Biol Chem. June 20, 2003; 278 (25): 22437-45.

Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis., Gormley JP, Nascone-Yoder NM., Dev Genes Evol. August 1, 2003; 213 (8): 390-8.

Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis., Dagle JM, Sabel JL, Littig JL, Sutherland LB, Kolker SJ, Weeks DL., Dev Biol. October 15, 2003; 262 (2): 268-81.

Left-right asymmetric morphogenesis in the Xenopus digestive system., Muller JK, Prather DR, Nascone-Yoder NM., Dev Dyn. December 1, 2003; 228 (4): 672-82.          

ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus., Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF., Dev Biol. April 15, 2004; 268 (2): 280-94.      

Xenopus nodal related-1 is indispensable only for left-right axis determination., Toyoizumi R, Ogasawara T, Takeuchi S, Mogi K., Int J Dev Biol. January 1, 2005; 49 (8): 923-38.                

Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease., Ramsdell AF, Bernanke JM, Trusk TC., Development. April 1, 2006; 133 (7): 1399-410.                    

Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos., Toyoizumi R, Takeuchi S, Mogi K., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.

Cilia-driven leftward flow determines laterality in Xenopus., Schweickert A, Weber T, Beyer T, Vick P, Bogusch S, Feistel K, Blum M., Curr Biol. January 9, 2007; 17 (1): 60-6.        

Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus., Ohi Y, Wright CV., Dev Biol. January 15, 2007; 301 (2): 447-63.

The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos., Vonica A, Brivanlou AH., Dev Biol. March 1, 2007; 303 (1): 281-94.              

Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination., Hilton EN, Manson FD, Urquhart JE, Johnston JJ, Slavotinek AM, Hedera P, Stattin EL, Nordgren A, Biesecker LG, Black GC., Hum Mol Genet. July 15, 2007; 16 (14): 1773-82.              

Lessons from the lily pad: Using Xenopus to understand heart disease., Bartlett HL, Weeks DL., Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.

The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities., Tian J, Andrée B, Jones CM, Sampath K., Development. August 1, 2008; 135 (15): 2649-58.  

Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic., Schweickert A, Deissler K, Britsch S, Albrecht M, Ehmann H, Mauch V, Gaio U, Blum M., Dev Dyn. December 1, 2008; 237 (12): 3557-64.    

Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis., Vick P, Schweickert A, Weber T, Eberhardt M, Mencl S, Shcherbakov D, Beyer T, Blum M., Dev Biol. July 15, 2009; 331 (2): 281-91.                                        

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow., Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB., Development. September 1, 2009; 136 (17): 3019-30.  

Retinoic acid regulates anterior-posterior patterning within the lateral plate mesoderm of Xenopus., Deimling SJ, Drysdale TA., Mech Dev. October 1, 2009; 126 (10): 913-23.                        

Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis., Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelrod JD., PLoS One. February 2, 2010; 5 (2): e8999.          

BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning., Sakano D, Kato A, Parikh N, McKnight K, Terry D, Stefanovic B, Kato Y., Dev Cell. March 16, 2010; 18 (3): 450-62.        

Conservation, development, and function of a cement gland-like structure in the fish Astyanax mexicanus., Pottin K, Hyacinthe C, Rétaux S., Proc Natl Acad Sci U S A. October 5, 2010; 107 (40): 17256-61.

???pagination.result.page??? 1 2 3 ???pagination.result.next???